HitPredict

Interactor 1: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Interactor 2: ERBIN (Q96RT1)
Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)
Gene: ERBIN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	17591701, 12650946, 18003620, 18729074
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 1412
+	Mm
		1193433 SMAD3_MOUSE (1-425): 0: 636: 100.00		ERBIN_MOUSE (8-1412): 0: 874: 88.55
+	Hs
		1078632 SMAD2_HUMAN (1-425): 0: 589: 83.73		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Hs
		1078748 SMAD1_HUMAN (1-425): 0: 559: 60.09		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Mm
		1143944 SMAD2_MOUSE (1-425): 0: 591: 83.73		ERBIN_MOUSE (8-1412): 0: 874: 88.55
+	Mm
		936612 SMAD1_MOUSE (1-425): 0: 560: 59.87		ERBIN_MOUSE (8-1412): 0: 874: 88.55
+	Hs
		1035562 SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Mm
		956547 SMAD4_MOUSE (23-414): 2.27e-119: 360: 32.88		ERBIN_MOUSE (8-1412): 0: 874: 88.55
+	Hs
		167386 SMAD7_HUMAN (28-403): 2.71e-101: 309: 27.06		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Mm
		192487 SMAD7_MOUSE (28-403): 8.69e-99: 303: 27.06		ERBIN_MOUSE (8-1412): 0: 874: 88.55
+	Dm
		785460 MAD_DROME (1-425): 0: 571: 61.09		SCRIB_DROME (1095-1408): 4.08e-16: 86.8: 16.82