HitPredict

Interactor 1: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Interactor 2: IQGA2 (Q13576)
Ras GTPase-activating-like protein IQGAP2
Gene: IQGAP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	12376551, 31871319
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030667 - secretory granule membrane GO:0032956 - regulation of actin cytoskeleton organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1575
+	Hs
		925259 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		IQGA2_HUMAN (1-1575): 0: 1336: 100.00
+	Hs
		809255 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		IQGA1_HUMAN (9-1575): 0: 1223: 55.99
+	Hs
		809264 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		IQGA1_HUMAN (9-1575): 0: 1223: 55.99
+	Hs
		809241 RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62		IQGA1_HUMAN (9-1575): 0: 1223: 55.99
+	Mm
		925821 RAC1_MOUSE (1-191): 3.6e-82: 243: 71.88		IQGA1_MOUSE (11-1575): 0: 1211: 55.45
+	Hs
		925404 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		IQGA3_HUMAN (18-1575): 0: 1209: 47.63
+	Mm
		892736 CDC42_MOUSE (1-191): 1.3e-78: 234: 60.73		IQGA1_MOUSE (11-1575): 0: 1211: 55.45
+	Hs
		900647 RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62		IQGA3_HUMAN (18-1575): 0: 1209: 47.63
+	Dd
		710113 RAC1A_DICDI (1-191): 4.8e-80: 238: 68.04		RGAA_DICDI (754-1573): 1.31e-124: 412: 28.73
+	Hs
		925728 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		MYO5B_HUMAN (142-1456): 5.01e-105: 373: 11.77
+	Dd
		136239 RAC1A_DICDI (1-191): 4.8e-80: 238: 68.04		GAPA_DICDI (734-1574): 2.21e-111: 376: 26.94
+	Hs
		925347 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		DAB2P_HUMAN (733-1359): 1.86e-79: 289: 13.92
+	Hs
		951073 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		DAB2P_HUMAN (733-1359): 1.86e-79: 289: 13.92
+	Hs
		598457 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		NF1_HUMAN (841-1304): 1.31e-77: 287: 18.96
+	Hs
		925715 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		NGAP_HUMAN (733-1354): 3.35e-77: 282: 14.69
+	Hs
		951447 RHOG_HUMAN (1-191): 9.12e-82: 242: 100.00		NGAP_HUMAN (733-1354): 3.35e-77: 282: 14.69
+	Hs
		598453 RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62		NF1_HUMAN (841-1304): 1.31e-77: 287: 18.96
+	Hs
		901032 RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62		NGAP_HUMAN (733-1354): 3.35e-77: 282: 14.69
+	Hs
		925530 RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61
+	Hs
		900814 RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61