Protein: RLMKL
Ribosomal RNA large subunit methyltransferase K/L [Includes: 23S rRNA m2G2445 methyltransferase (EC 2.1.1.173) (rRNA (guanine-N(2)-)-methyltransferase RlmL); 23S rRNA m7G2069 methyltransferase (EC 2.1.1.264) (rRNA (guanine-N(7)-)-methyltransferase RlmK)]

Gene: RLMKL, rlmL
Organism: Escherichia coli K-12
Interactions: 51
UniProt ID: P75864

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005737 - cytoplasm
GO:0008990 - rRNA (guanine-N2-)-methyltransferase activity
GO:0031167 - rRNA methylation
GO:0052915 - 23S rRNA (guanine(2445)-N(2))-methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

492795

RL1
Large ribosomal subunit protein uL1

3

1

High-throughput

0.657

High

790856

RLUB
Ribosomal large subunit pseudouridine synthase B

2

3

High-throughput

0.640

High

496271

CSPD
Cold shock-like protein CspD

2

3

High-throughput

0.588

High

497392

CSPA
Cold shock protein CspA

2

3

High-throughput

0.588

High

663213

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

2

0

High-throughput

0.585

High

788382

RLMN
Dual-specificity RNA methyltransferase RlmN

2

0

High-throughput

0.585

High

491958

RPPH
RNA pyrophosphohydrolase

2

0

High-throughput

0.563

High

498007

YBCJ
Putative RNA-binding protein YbcJ

2

0

High-throughput

0.563

High

497653

RLUC
Ribosomal large subunit pseudouridine synthase C

1

3

High-throughput

0.561

High

493994

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.536

High

497676

RSUA
Ribosomal small subunit pseudouridine synthase A

1

3

High-throughput

0.536

High

638590

RNR
Ribonuclease R

1

1

High-throughput

0.536

High

950976

RL2
Large ribosomal subunit protein uL2

1

1

High-throughput

0.536

High

949487

RAPA
RNA polymerase-associated protein RapA

1

0

High-throughput

0.518

High

382755

RS7
Small ribosomal subunit protein uS7

1

0

High-throughput

0.513

High

494194

RS4
Small ribosomal subunit protein uS4

1

0

High-throughput

0.513

High

494509

RS9
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

501212

RL17
Large ribosomal subunit protein bL17

1

0

High-throughput

0.513

High

636376

CATE
Catalase HPII

1

0

High-throughput

0.513

High

638637

RNE
Ribonuclease E

1

0

High-throughput

0.513

High

639472

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

1

0

High-throughput

0.513

High

951034

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.513

High

1003701

LSRK
Autoinducer-2 kinase

1

0

High-throughput

0.513

High

638619

SRMB
ATP-dependent RNA helicase SrmB

1

1

High-throughput

0.489

High

496307

CSPE
Cold shock-like protein CspE

1

3

High-throughput

0.484

High

497444

CSPC
Cold shock-like protein CspC

1

3

High-throughput

0.484

High

490914

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

494901

TGT
Queuine tRNA-ribosyltransferase

1

0

High-throughput

0.464

High

501624

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

0

High-throughput

0.464

High

498317

PCNB
Poly(A) polymerase I

1

0

High-throughput

0.458

High

495595

TMAR
Pole-localizer protein TmaR

1

1

High-throughput

0.437

High

368524

MANA
Mannose-6-phosphate isomerase

2

0

High-throughput

0.322

High

495454

TRMB
tRNA

2

0

High-throughput

0.307

High

498734

FLIG
Flagellar motor switch protein FliG

1

0

High-throughput

0.282

High

421083

APPY
HTH-type transcriptional regulator AppY

1

0

High-throughput

0.279

Low

498471

NAPC
Cytochrome c-type protein NapC

1

0

High-throughput

0.279

Low

499505

YEBG
Uncharacterized protein YebG

1

0

High-throughput

0.279

Low

616994

NADE
NH(3)-dependent NAD(+) synthetase

1

0

High-throughput

0.279

Low

664138

FDNG
Formate dehydrogenase, nitrate-inducible, major subunit

1

0

High-throughput

0.279

Low

722846

3PASE
Inorganic triphosphatase

1

0

High-throughput

0.279

Low

1003699

YNBC
Uncharacterized protein YnbC

1

0

High-throughput

0.279

Low

1003700

YFGI
Uncharacterized protein YfgI

1

0

High-throughput

0.279

Low

1003702

MOCA
Molybdenum cofactor cytidylyltransferase

1

0

High-throughput

0.279

Low

517303

BIPA
Large ribosomal subunit assembly factor BipA

1

0

High-throughput

0.276

Low

494584

RNPA
Ribonuclease P protein component

1

0

High-throughput

0.253

Low

495414

YIHI
Der GTPase-activating protein YihI

1

0

High-throughput

0.253

Low

496743

PHOL
PhoH-like protein

1

0

High-throughput

0.253

Low

497124

DEAD
ATP-dependent RNA helicase DeaD

1

0

High-throughput

0.253

Low

500312

FABI
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

1

0

High-throughput

0.253

Low

501113

SPOT
Bifunctional

1

0

High-throughput

0.249

Low

999718

CSRA
Carbon storage regulator

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025