HitPredict

Interactor 1: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Interactor 2: SRSF2 (Q01130)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	22365833
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 221
+	Hs
		951977 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24
+	Zm
		30171 A0A1D6M1U3_MAIZE (5-85): 1.01e-30: 115: 42.17		A0A1D6K4S7_MAIZE (3-93): 2.97e-41: 146: 47.83
+	Hs
		963995 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00
+	Hs
		516466 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Hs
		516478 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Hs
		963969 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00
+	Hs
		266904 SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Hs
		963976 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00
+	Hs
		951937 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79
+	Hs
		992743 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79
+	Hs
		1084384 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRSF8_HUMAN (1-183): 4.13e-29: 111: 63.39
+	Zm
		18728 A0A1D6H7I7_MAIZE (10-163): 3.59e-27: 105: 29.59		O48554_MAIZE (17-91): 5.3e-30: 110: 37.33
+	Hs
		952100 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		SRSF8_HUMAN (1-183): 4.13e-29: 111: 63.39
+	Hs
		1028792 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		SRSF8_HUMAN (1-183): 4.13e-29: 111: 63.39
+	Hs
		992984 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		PUF60_HUMAN (8-108): 1.34e-23: 100: 23.76
+	Hs
		474017 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		PAB4L_HUMAN (15-92): 1.09e-20: 90.5: 26.92
+	Hs
		992875 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		PABP5_HUMAN (16-95): 2.11e-18: 84.4: 21.25
+	Mm
		857340 SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65		TIA1_MOUSE (7-184): 8.63e-17: 79.6: 11.67
+	Hs
		680437 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		TIA1_HUMAN (9-184): 2.34e-16: 78.5: 10.67
+	Mm
		936481 SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65		TIAR_MOUSE (9-140): 1.67e-15: 76.2: 9.85