HitPredict

Interactor 1: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 282
+	Hs
		1084384 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		963995 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		951927 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		963969 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		963976 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		1084450 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Zm
		30171 A0A1D6M1U3_MAIZE (5-85): 1.01e-30: 115: 42.17		A0A1D6K4S7_MAIZE (1-146): 3.08e-30: 119: 35.81
+	At
		1163070 SR30_ARATH (5-90): 4.74e-26: 101: 44.32		CYP59_ARATH (2-263): 2.25e-33: 129: 16.98
+	Hs
		952176 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		951937 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		992743 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516466 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		516478 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		680437 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		TIA1_HUMAN (12-190): 8.64e-19: 87.2: 12.02
+	Zm
		18728 A0A1D6H7I7_MAIZE (10-163): 3.59e-27: 105: 29.59		O48554_MAIZE (17-91): 4.8e-18: 80.7: 36.00
+	Hs
		951962 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		CIRBP_HUMAN (16-160): 2.29e-19: 85: 33.79
+	Mm
		857340 SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	At
		1247085 Q8RWF8_ARATH (11-162): 3.43e-25: 100: 27.39		Q8RWF8_ARATH (10-248): 2.41e-17: 82.6: 26.56
+	At
		1093121 SR30_ARATH (5-90): 4.74e-26: 101: 44.32		SRC28_ARATH (9-182): 2.52e-17: 80.7: 30.86
+	Mm
		936481 SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65		TIAR_MOUSE (12-152): 9.18e-17: 81.4: 12.68