HitPredict

Interactor 1: POF1 (P87053)
F-box/WD repeat-containing protein pof1 (Skp1-binding protein 1)
Gene: POF1

Interactor 2: SKP1 (Q9Y709)
Suppressor of kinetochore protein 1 (P19/Skp1 homolog)
Gene: SKP1

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.891

Property	Details
Experiments	11820777, 15147268, 26771498, 19748355
Identification Methods	two hybrid, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005634 - nucleus GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 605 Sp			1 161
+	Dm
		285042 FBXW7_DROME (298-604): 1.73e-87: 298: 26.43		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Mm
		1257397 FBXW7_MOUSE (339-602): 5.75e-76: 257: 32.59		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Hs
		929021 FBXW7_HUMAN (339-602): 2.33e-75: 255: 32.59		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Sc
		431143 CDC4_YEAST (45-560): 1.78e-80: 271: 20.21		SKP1_YEAST (2-161): 5.56e-66: 201: 50.00
+	Ce
		105479 SEL10_CAEEL (338-599): 1.1e-67: 232: 28.04		SKR1_CAEEL (3-160): 1.7e-78: 232: 56.10
+	Sp
		144900 POP2_SCHPO (356-602): 9.52e-49: 182: 20.83		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Sp
		953235 POP1_SCHPO (356-589): 8.94e-48: 180: 18.97		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Hs
		929125 FBW1A_HUMAN (462-603): 2.16e-25: 112: 15.97		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Mm
		1131317 FBW1B_MOUSE (462-603): 5.5e-25: 111: 16.67		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Mm
		1112932 FBW1A_MOUSE (462-603): 9.48e-25: 110: 15.97		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Hs
		929110 FBW1B_HUMAN (462-603): 8.89e-25: 110: 16.67		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Xl
		1174984 TRCB_XENLA (462-603): 1.09e-24: 109: 15.97		SKP1_XENLA (1-161): 9e-82: 240: 55.76
+	Dm
		218244 O44382_DROME (474-603): 1.26e-24: 109: 19.70		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Dm
		285012 Q9VDE3_DROME (474-603): 1.45e-24: 109: 19.70		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Hs
		928946 FBW10_HUMAN (326-542): 4.73e-19: 93.6: 30.97		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Dm
		1180601 Q9VDE3_DROME (474-603): 1.45e-24: 109: 19.70		Q7KJ69_DROME (1-161): 4.35e-74: 220: 53.37
+	Sp
		1000009 POF11_SCHPO (461-604): 1.26e-16: 84.9: 15.97		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Dm
		1363661 Q9VDE3_DROME (474-603): 1.45e-24: 109: 19.70		Q9VWC4_DROME (2-151): 2.3e-65: 198: 47.71
+	Sc
		759309 MET30_YEAST (499-605): 2.92e-18: 90.7: 14.82		SKP1_YEAST (2-161): 5.56e-66: 201: 50.00
+	Ce
		105997 LIN23_CAEEL (512-599): 5.41e-17: 86.5: 17.05		G5EDD8_CAEEL (3-160): 3.13e-67: 203: 46.34