HitPredict

Interactor 1: JUN (P17325)
Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog)
Gene: JUN

Interactor 2: MK10 (P49187)
Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (SAPK-beta) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (p54-beta)
Gene: Mapk10

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20421303
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 334 Rn			1 464
+	Hs
		401690 JUN_HUMAN (1-334): 7.56e-96: 289: 94.91		MK10_HUMAN (1-464): 1.08e-180: 514: 99.14
+	Rn
		567364 JUN_RAT (1-334): 2.24e-99: 298: 100.00		MK09_RAT (39-464): 5.82e-161: 463: 83.10
+	Hs
		401593 JUN_HUMAN (1-334): 7.56e-96: 289: 94.91		MK09_HUMAN (39-464): 2.94e-162: 466: 83.80
+	Hs
		401592 JUN_HUMAN (1-334): 7.56e-96: 289: 94.91		MK08_HUMAN (39-464): 5.26e-161: 463: 90.87
+	Rn
		567363 JUN_RAT (1-334): 2.24e-99: 298: 100.00		MK08_RAT (39-448): 1.55e-155: 448: 90.02
+	Mm
		404155 JUN_MOUSE (1-334): 3.28e-99: 297: 99.40		MK08_MOUSE (39-419): 2.16e-150: 435: 91.86
+	Hs
		568080 JUND_HUMAN (5-334): 3.45e-59: 195: 47.40		MK10_HUMAN (1-464): 1.08e-180: 514: 99.14
+	Hs
		566735 JUNB_HUMAN (1-334): 7.23e-73: 231: 44.32		MK09_HUMAN (39-464): 2.94e-162: 466: 83.80
+	Hs
		566734 JUNB_HUMAN (1-334): 7.23e-73: 231: 44.32		MK08_HUMAN (39-464): 5.26e-161: 463: 90.87
+	Hs
		402080 JUN_HUMAN (1-334): 7.56e-96: 289: 94.91		MK14_HUMAN (42-407): 2.34e-132: 388: 46.07
+	Hs
		568074 JUND_HUMAN (5-334): 3.45e-59: 195: 47.40		MK09_HUMAN (39-464): 2.94e-162: 466: 83.80
+	Hs
		568073 JUND_HUMAN (5-334): 3.45e-59: 195: 47.40		MK08_HUMAN (39-464): 5.26e-161: 463: 90.87
+	Hs
		568251 ATF7_HUMAN (42-332): 4.18e-48: 170: 19.73		MK08_HUMAN (39-464): 5.26e-161: 463: 90.87
+	Dm
		576061 JRA_DROME (7-327): 3.94e-44: 154: 26.63		JNK_DROME (47-411): 9.25e-144: 417: 77.60
+	Hs
		401456 JUN_HUMAN (1-334): 7.56e-96: 289: 94.91		MK03_HUMAN (58-397): 9.65e-85: 266: 42.12
+	Hs
		401473 JUN_HUMAN (1-334): 7.56e-96: 289: 94.91		MK01_HUMAN (53-397): 7.33e-85: 266: 42.66
+	Dm
		247434 JRA_DROME (7-327): 3.94e-44: 154: 26.63		MK38B_DROME (39-403): 8.49e-136: 396: 43.94
+	Dm
		248406 JRA_DROME (7-327): 3.94e-44: 154: 26.63		MK38A_DROME (41-404): 1.93e-134: 393: 45.41
+	Hs
		568066 JUND_HUMAN (5-334): 3.45e-59: 195: 47.40		MK01_HUMAN (53-397): 7.33e-85: 266: 42.66
+	Hs
		647549 CREM_HUMAN (25-306): 6.72e-45: 158: 15.20		MK03_HUMAN (58-397): 9.65e-85: 266: 42.12