HitPredict

Interactor 1: CDK2 (P97377)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2)
Gene: CDK2

Interactor 2: CCNC (Q62447)
Cyclin-C
Gene: CCNC

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25344755
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cyclin_C_2~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 346 Mm			1 283
+	Mm
		956329 CDK2_MOUSE (1-346): 6.83e-152: 432: 100.00		CCNA1_MOUSE (10-270): 3.37e-78: 244: 17.60
+	Mm
		851183 CDK2_MOUSE (1-346): 6.83e-152: 432: 100.00		CCNA2_MOUSE (2-268): 9.91e-75: 236: 15.69
+	Hs
		538471 CDK2_HUMAN (1-346): 6.94e-142: 405: 82.95		CCNB1_HUMAN (1-277): 4.92e-82: 255: 14.89
+	Hs
		625350 CDK2_HUMAN (1-346): 6.94e-142: 405: 82.95		CCNA1_HUMAN (2-262): 1.61e-78: 247: 17.74
+	Hs
		303829 CDK2_HUMAN (1-346): 6.94e-142: 405: 82.95		CCNB2_HUMAN (1-276): 3.42e-77: 241: 13.88
+	Hs
		590125 CDK2_HUMAN (1-346): 6.94e-142: 405: 82.95		CCNA2_HUMAN (2-263): 3.88e-75: 237: 15.36
+	Hs
		538521 CDK3_HUMAN (1-342): 3.1e-134: 385: 63.74		CCNB1_HUMAN (1-277): 4.92e-82: 255: 14.89
+	Hs
		624422 CDK3_HUMAN (1-342): 3.1e-134: 385: 63.74		CCNC_HUMAN (1-283): 1.34e-79: 244: 99.29
+	Hs
		590162 CDK3_HUMAN (1-342): 3.1e-134: 385: 63.74		CCNA2_HUMAN (2-263): 3.88e-75: 237: 15.36
+	Mm
		673122 CDK2_MOUSE (1-346): 6.83e-152: 432: 100.00		CCND2_MOUSE (10-275): 3.85e-57: 186: 15.75
+	Dm
		618425 CDK2_DROME (1-337): 1.13e-131: 379: 55.49		CCNC_DROME (1-256): 1.67e-75: 232: 71.60
+	Dm
		625700 CDK5_DROME (1-336): 2.08e-128: 371: 50.00		CCNC_DROME (1-256): 1.67e-75: 232: 71.60
+	Dm
		618463 CDK2_DROME (1-337): 1.13e-131: 379: 55.49		Q961D1_DROME (14-278): 2.69e-67: 216: 25.62
+	Rn
		981205 Q6P751_RAT (1-346): 1.09e-141: 404: 83.82		CCND2_RAT (10-275): 3.76e-56: 184: 16.18
+	Hs
		625251 CDK2_HUMAN (1-346): 6.94e-142: 405: 82.95		CCNH_HUMAN (5-263): 2.23e-54: 180: 22.87
+	Hs
		625155 CDK2_HUMAN (1-346): 6.94e-142: 405: 82.95		CCND2_HUMAN (10-275): 1.4e-53: 177: 16.54
+	Hs
		960107 CDK3_HUMAN (1-342): 3.1e-134: 385: 63.74		CCNQ_HUMAN (33-238): 1.91e-57: 186: 21.97
+	Hs
		851197 CDK3_HUMAN (1-342): 3.1e-134: 385: 63.74		CCNH_HUMAN (5-263): 2.23e-54: 180: 22.87
+	Dm
		184388 CDK2_DROME (1-337): 1.13e-131: 379: 55.49		O17144_DROME (10-270): 6.03e-53: 177: 24.19
+	Dm
		283943 CDK2_DROME (1-337): 1.13e-131: 379: 55.49		O76513_DROME (10-270): 5.51e-53: 177: 24.19