Protein: ZFY27
Protrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27)

Gene: ZFY27, ZFYVE27
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q5T4F4

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1212769

VAPA
Vesicle-associated membrane protein-associated protein A

4

3

Small-scale

0.708

High

1212750

MSPD2
Motile sperm domain-containing protein 2

2

1

High-throughput

0.628

High

1027037

REEP5
Receptor expression-enhancing protein 5

2

1

Small-scale

0.611

High

252604

TSN2
Tetraspanin-2

2

1

High-throughput

0.606

High

1212754

GIMA1
GTPase IMAP family member 1

2

1

High-throughput

0.606

High

403179

APOB
Apolipoprotein B-100

2

0

High-throughput

0.602

High

1212752

ZFN2B
AN1-type zinc finger protein 2B

2

0

High-throughput

0.602

High

1212737

ZFY27
Protrudin

1

0

Small-scale

0.586

High

1212760

SEC62
Translocation protein SEC62

2

0

High-throughput

0.585

High

901293

RAB7A
Ras-related protein Rab-7a

2

2

Small-scale

0.584

High

325555

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

1212741

TMM65
Transmembrane protein 65

2

0

High-throughput

0.580

High

1212745

ZNT8
Proton-coupled zinc antiporter SLC30A8

2

0

High-throughput

0.580

High

1212746

S66A2
Solute carrier family 66 member 2

2

0

High-throughput

0.580

High

1212759

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.580

High

1212768

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

0

High-throughput

0.580

High

1212770

ORML1
ORM1-like protein 1

2

0

High-throughput

0.580

High

1212776

IR3IP
Immediate early response 3-interacting protein 1

2

0

High-throughput

0.580

High

443822

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

2

1

High-throughput

0.574

High

680385

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

2

1

High-throughput

0.574

High

1125476

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

2

0

Small-scale

0.566

High

1212758

GIMA5
GTPase IMAP family member 5

2

1

High-throughput

0.553

High

956332

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.536

High

1212740

ATLA3
Atlastin-3

1

2

Small-scale

0.536

High

1212749

ATLA2
Atlastin-2

1

2

Small-scale

0.536

High

1212755

ATLA1
Atlastin-1

1

2

Small-scale

0.536

High

976321

RB11A
Ras-related protein Rab-11A

1

1

Small-scale

0.515

High

127989

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.513

High

144273

ACACB
Acetyl-CoA carboxylase 2

1

0

High-throughput

0.513

High

238908

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

High-throughput

0.513

High

349439

TSN15
Tetraspanin-15

1

0

High-throughput

0.513

High

463123

YES
Tyrosine-protein kinase Yes

1

0

High-throughput

0.513

High

1134609

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.493

High

422285

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

333039

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

3

Small-scale

0.479

High

876002

TCPE
T-complex protein 1 subunit epsilon

1

2

Small-scale

0.479

High

881961

TCPG
T-complex protein 1 subunit gamma

1

2

Small-scale

0.479

High

899425

TCPD
T-complex protein 1 subunit delta

1

2

Small-scale

0.479

High

1212766

REEP1
Receptor expression-enhancing protein 1

1

1

Small-scale

0.479

High

173948

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

418191

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

1113323

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1212738

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1212739

FBW10
F-box/WD repeat-containing protein 10

1

0

High-throughput

0.458

High

1212743

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1212748

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1212756

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1212762

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1212763

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1212764

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1212765

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1212767

SAR1A
Small COPII coat GTPase SAR1A

1

0

High-throughput

0.458

High

1212772

SPAST
Spastin

1

0

Small-scale

0.458

High

1212753

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

256050

S19A2
Thiamine transporter 1

2

0

High-throughput

0.328

High

397803

ATP8
ATP synthase F(0) complex subunit 8

2

0

High-throughput

0.328

High

665611

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

2

0

High-throughput

0.328

High

912678

CTR2
Cationic amino acid transporter 2

2

0

High-throughput

0.328

High

1212742

PXDC2
Plexin domain-containing protein 2

2

0

High-throughput

0.328

High

1212751

GOGA5
Golgin subfamily A member 5

2

0

High-throughput

0.328

High

1212757

ENTR1
Endosome-associated-trafficking regulator 1

2

0

High-throughput

0.328

High

189615

STX7
Syntaxin-7

2

0

High-throughput

0.316

High

1203311

TM128
Transmembrane protein 128

2

0

High-throughput

0.316

High

1212744

OTOP3
Proton channel OTOP3

2

0

High-throughput

0.316

High

1212747

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

2

0

High-throughput

0.316

High

1212761

TM243
Transmembrane protein 243

2

0

High-throughput

0.316

High

1212771

TM14C
Transmembrane protein 14C

2

0

High-throughput

0.316

High

226429

SNG2
Synaptogyrin-2

1

0

High-throughput

0.279

Low

298728

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.279

Low

536256

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.279

Low

784634

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

1101508

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1212773

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.279

Low

1212774

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

1212775

T184B
Transmembrane protein 184B

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025