HitPredict

Interactor 1: DOK1 (P97465)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok))
Gene: DOK1

Interactor 2: Q91YX7 (Q91YX7)
RAS p21 protein activator 1
Gene: Rasa1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	20697350
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	IRS~PH, PH~PH, PH~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Mm			1 813
+	Mm
		250956 DOK2_MOUSE (2-425): 3.71e-101: 311: 33.11		Q91YX7_MOUSE (1-813): 0: 659: 100.00
+	Mm
		956520 DOK1_MOUSE (1-482): 0: 545: 100.00		GRB2_MOUSE (50-221): 5.65e-60: 204: 26.86
+	Hs
		924816 DOK1_HUMAN (1-482): 0: 526: 83.44		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Mm
		93305 DOK1_MOUSE (1-482): 0: 545: 100.00		E9PYG6_MOUSE (91-296): 6.82e-19: 94: 18.57
+	Rn
		842411 DOK1_RAT (1-482): 0: 541: 93.78		RASA1_RAT (91-296): 1.1e-18: 93.6: 18.57
+	Hs
		596429 DOK1_HUMAN (1-482): 0: 526: 83.44		RASA1_HUMAN (87-296): 1.11e-18: 93.6: 18.69
+	Mm
		1141171 DOK3_MOUSE (1-460): 1.73e-119: 359: 30.30		GRB2_MOUSE (50-221): 5.65e-60: 204: 26.86
+	Hs
		924665 DOK3_HUMAN (1-460): 4.5e-119: 360: 30.85		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Hs
		151763 IRS4_HUMAN (6-406): 7.52e-92: 305: 14.29		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Mm
		946348 IRS2_MOUSE (6-370): 2.17e-73: 253: 13.82		GRB2_MOUSE (50-221): 5.65e-60: 204: 26.86
+	Rn
		94388 F1MAL5_RAT (6-370): 1.89e-72: 251: 13.82		GRB2_RAT (50-210): 1.12e-59: 203: 28.92
+	Hs
		924725 FRS2_HUMAN (135-478): 2.91e-75: 247: 20.31		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Rn
		724631 IRS1_RAT (6-365): 6.72e-71: 246: 16.27		GRB2_RAT (50-210): 1.12e-59: 203: 28.92
+	Hs
		924983 IRS2_HUMAN (6-368): 7.77e-71: 246: 12.78		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Mm
		724599 IRS1_MOUSE (6-365): 2.62e-70: 244: 16.27		GRB2_MOUSE (50-221): 5.65e-60: 204: 26.86
+	Mm
		1141149 FRS2_MOUSE (135-478): 4.6e-72: 238: 19.54		GRB2_MOUSE (50-221): 5.65e-60: 204: 26.86
+	Rn
		88884 D4A244_RAT (135-478): 2.2e-72: 239: 19.79		GRB2_RAT (50-210): 1.12e-59: 203: 28.92
+	Hs
		724527 IRS1_HUMAN (6-360): 6.38e-68: 237: 16.01		GRB2_HUMAN (50-210): 1.12e-59: 203: 28.92
+	Hs
		235043 DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16		RASA1_HUMAN (87-296): 1.11e-18: 93.6: 18.69
+	Mm
		93301 DOK2_MOUSE (2-425): 3.71e-101: 311: 33.11		E9PYG6_MOUSE (91-296): 6.82e-19: 94: 18.57