Protein: RPB4
DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)

Gene: RPB4, POLR2D
Organism: Homo sapiens
Interactions: 131
UniProt ID: O15514

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005665 - RNA polymerase II, core complex
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181407

RPB7
DNA-directed RNA polymerase II subunit RPB7

8

4

Small-scale

0.972

High

181390

RPB1
DNA-directed RNA polymerase II subunit RPB1

7

8

Small-scale

0.967

High

181442

MED8
Mediator of RNA polymerase II transcription subunit 8

2

0

High-throughput

0.770

High

181466

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

High-throughput

0.770

High

181400

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

6

2

Small-scale

0.736

High

181387

RPB3
DNA-directed RNA polymerase II subunit RPB3

5

4

Small-scale

0.723

High

181388

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

5

1

Small-scale

0.723

High

181392

RPB2
DNA-directed RNA polymerase II subunit RPB2

5

3

Small-scale

0.723

High

181435

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

5

1

High-throughput

0.722

High

181409

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

5

1

Small-scale

0.721

High

181463

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

4

6

High-throughput

0.699

High

181367

MCE1
mRNA-capping enzyme

4

1

High-throughput

0.694

High

181431

SPT6H
Transcription elongation factor SPT6

1

1

High-throughput

0.691

High

181472

PIHD1
PIH1 domain-containing protein 1

5

0

High-throughput

0.684

High

181395

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

4

High-throughput

0.675

High

181406

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

1

High-throughput

0.675

High

181446

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

3

5

High-throughput

0.675

High

48589

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

High-throughput

0.674

High

181370

RECQ5
ATP-dependent DNA helicase Q5

4

0

Small-scale

0.674

High

181399

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

1

Small-scale

0.670

High

125013

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

3

Small-scale

0.656

High

181374

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.646

High

181415

MED21
Mediator of RNA polymerase II transcription subunit 21

3

0

High-throughput

0.646

High

181450

MED10
Mediator of RNA polymerase II transcription subunit 10

3

0

High-throughput

0.646

High

123787

SPT5H
Transcription elongation factor SPT5

2

1

High-throughput

0.628

High

181365

MED14
Mediator of RNA polymerase II transcription subunit 14

2

4

High-throughput

0.628

High

181391

RBTN2
Rhombotin-2

2

1

High-throughput

0.628

High

181402

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

1

High-throughput

0.628

High

181454

MED28
Mediator of RNA polymerase II transcription subunit 28

3

0

High-throughput

0.628

High

155964

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

8

High-throughput

0.618

High

181375

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

8

High-throughput

0.618

High

181486

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

4

High-throughput

0.618

High

181461

GPN1
GPN-loop GTPase 1

2

1

High-throughput

0.611

High

181481

GPN3
GPN-loop GTPase 3

3

1

High-throughput

0.609

High

181369

MED6
Mediator of RNA polymerase II transcription subunit 6

2

0

High-throughput

0.602

High

181419

MED1
Mediator of RNA polymerase II transcription subunit 1

2

0

High-throughput

0.602

High

181426

MED27
Mediator of RNA polymerase II transcription subunit 27

2

0

High-throughput

0.602

High

181441

CPNE2
Copine-2

2

0

High-throughput

0.602

High

181462

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.602

High

181471

MED9
Mediator of RNA polymerase II transcription subunit 9

2

0

High-throughput

0.602

High

181473

ASB6
Ankyrin repeat and SOCS box protein 6

2

0

High-throughput

0.602

High

181474

MED29
Mediator of RNA polymerase II transcription subunit 29

2

0

High-throughput

0.602

High

181408

H4
Histone H4

2

0

High-throughput

0.585

High

181434

ARHGJ
Rho guanine nucleotide exchange factor 19

2

0

High-throughput

0.547

High

181413

EMX1
Homeobox protein EMX1

1

1

High-throughput

0.541

High

181394

T2FA
General transcription factor IIF subunit 1

1

1

High-throughput

0.536

High

181411

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.536

High

181414

SSRP1
FACT complex subunit SSRP1

1

3

High-throughput

0.536

High

181422

H2B2E
Histone H2B type 2-E

1

3

High-throughput

0.536

High

181423

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

3

High-throughput

0.536

High

181451

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

2

High-throughput

0.536

High

181453

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

High-throughput

0.536

High

181456

SFR19
Splicing factor, arginine/serine-rich 19

1

1

High-throughput

0.536

High

181487

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

3

High-throughput

0.536

High

181382

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

2

0

High-throughput

0.528

High

181393

HXC9
Homeobox protein Hox-C9

1

0

High-throughput

0.518

High

181437

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.518

High

181488

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.518

High

181372

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.513

High

181379

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

181380

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

181383

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

181389

TBP
TATA-box-binding protein

1

0

High-throughput

0.513

High

181398

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

181401

LIMK1
LIM domain kinase 1

1

0

High-throughput

0.513

High

181410

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

High-throughput

0.513

High

181416

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.513

High

181418

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

High-throughput

0.513

High

181421

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

181428

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.513

High

181433

RBM45
RNA-binding protein 45

1

0

High-throughput

0.513

High

181440

CUL5
Cullin-5

1

0

High-throughput

0.513

High

181443

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.513

High

181448

EPAS1
Endothelial PAS domain-containing protein 1

1

0

High-throughput

0.513

High

181457

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

181460

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

0

High-throughput

0.513

High

181464

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

181470

FANCL
E3 ubiquitin-protein ligase FANCL

1

0

High-throughput

0.513

High

181475

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.513

High

181485

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

169739

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

4

High-throughput

0.479

High

181376

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

181377

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

181403

H2B1D
Histone H2B type 1-D

1

3

High-throughput

0.479

High

181412

ERCC6
DNA excision repair protein ERCC-6

1

1

Small-scale

0.479

High

181449

H2B1L
Histone H2B type 1-L

1

3

High-throughput

0.479

High

181455

RPAP3
RNA polymerase II-associated protein 3

1

1

High-throughput

0.479

High

181458

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

3

High-throughput

0.479

High

181469

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.479

High

181476

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

4

High-throughput

0.479

High

181484

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

4

High-throughput

0.479

High

179473

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

181364

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

181366

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

181368

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

181371

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.458

High

181378

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.458

High

181384

XRCC5
X-ray repair cross-complementing protein 5

1

0

Small-scale

0.458

High

181385

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

181386

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

181396

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

181397

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

181420

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

181424

INT3
Integrator complex subunit 3

1

0

High-throughput

0.458

High

181427

INT5
Integrator complex subunit 5

1

0

High-throughput

0.458

High

181436

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

181438

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

181452

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

181467

INT10
Integrator complex subunit 10

1

0

Small-scale

0.458

High

181468

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.458

High

181478

UXT
Protein UXT

1

0

High-throughput

0.458

High

181479

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

181480

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.458

High

181482

INT6
Integrator complex subunit 6

1

0

High-throughput

0.458

High

181483

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

0

High-throughput

0.458

High

181432

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

0

High-throughput

0.438

High

181404

ELOF1
Transcription elongation factor 1 homolog

1

1

Small-scale

0.437

High

181477

PHRF1
PHD and RING finger domain-containing protein 1

1

1

High-throughput

0.437

High

181405

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.426

High

181447

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

181459

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

181425

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

0

High-throughput

0.353

High

181430

SYDE1
Rho GTPase-activating protein SYDE1

2

0

High-throughput

0.328

High

181417

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.282

High

181373

CCN6
Cellular communication network factor 6

1

0

High-throughput

0.279

Low

181439

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

181429

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

181445

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.249

Low

181465

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.249

Low

181381

MYZAP
Myocardial zonula adherens protein

1

0

High-throughput

0.232

Low

181444

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024