HitPredict

Interactor 1: DOK1 (P97465)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok))
Gene: DOK1

Interactor 2: NCK1 (Q99M51)
SH2/SH3 adapter protein Nck1 (Cytoplasmic protein Nck1) (NCK adapter protein 1) (Nck-1)
Gene: NCK1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	20697350, 15148308
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Mm			1 377
+	Mm
		223011 DOK1_MOUSE (1-482): 0: 545: 100.00		NCK2_MOUSE (1-376): 3.34e-90: 278: 67.19
+	Hs
		557780 DOK1_HUMAN (1-482): 0: 526: 83.44		NCK1_HUMAN (1-377): 2.9e-97: 295: 98.94
+	Hs
		209149 DOK1_HUMAN (1-482): 0: 526: 83.44		NCK2_HUMAN (1-376): 7.37e-90: 277: 68.50
+	Mm
		643076 DOK1_MOUSE (1-482): 0: 545: 100.00		P85A_MOUSE (241-376): 2.56e-22: 100: 19.57
+	Mm
		782845 DOK1_MOUSE (1-482): 0: 545: 100.00		CSK_MOUSE (4-143): 8.51e-17: 83.3: 14.38
+	Hs
		433460 DOK1_HUMAN (1-482): 0: 526: 83.44		YES_HUMAN (6-152): 2.64e-22: 100: 19.87
+	Hs
		655452 DOK1_HUMAN (1-482): 0: 526: 83.44		P85A_HUMAN (241-376): 2.35e-22: 100: 19.57
+	Hs
		454844 DOK1_HUMAN (1-482): 0: 526: 83.44		FGR_HUMAN (6-130): 3.16e-22: 99.8: 21.26
+	Mm
		956520 DOK1_MOUSE (1-482): 0: 545: 100.00		GRB2_MOUSE (3-58): 7.7e-17: 80.6: 28.57
+	Hs
		442876 DOK1_HUMAN (1-482): 0: 526: 83.44		HCK_HUMAN (2-130): 1.23e-21: 98.3: 22.31
+	Mm
		623689 DOK1_MOUSE (1-482): 0: 545: 100.00		TEC_MOUSE (6-108): 1.15e-14: 77.5: 22.12
+	Hs
		523124 DOK1_HUMAN (1-482): 0: 526: 83.44		SRC_HUMAN (6-130): 5.78e-19: 90.1: 21.26
+	Hs
		789086 DOK1_HUMAN (1-482): 0: 526: 83.44		ABL2_HUMAN (197-356): 8.37e-16: 81.3: 33.95
+	Hs
		924816 DOK1_HUMAN (1-482): 0: 526: 83.44		GRB2_HUMAN (3-58): 7.33e-17: 80.6: 28.57
+	Hs
		789005 DOK1_HUMAN (1-482): 0: 526: 83.44		TEC_HUMAN (2-108): 4.89e-15: 78.7: 22.22
+	Hs
		208960 DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16		NCK2_HUMAN (1-376): 7.37e-90: 277: 68.50
+	Hs
		924665 DOK3_HUMAN (1-460): 4.5e-119: 360: 30.85		GRB2_HUMAN (3-58): 7.33e-17: 80.6: 28.57
+	Mm
		1141171 DOK3_MOUSE (1-460): 1.73e-119: 359: 30.30		GRB2_MOUSE (3-58): 7.7e-17: 80.6: 28.57
+	Hs
		235037 DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16		YES_HUMAN (6-152): 2.64e-22: 100: 19.87
+	Hs
		235036 DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16		FYN_HUMAN (6-130): 3.47e-22: 99.8: 21.26