HitPredict

Interactor 1: THIOM (P97493)
Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)
Gene: Txn2

Interactor 2: PRDX2 (Q61171)
Peroxiredoxin-2 (EC 1.11.1.24) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2)
Gene: PRDX2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	31018154
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	1-cysPrx_C~Thioredoxin, AhpC-TSA~Thioredoxin
Common GO terms	GO:0005739 - mitochondrion GO:0006979 - response to oxidative stress GO:0045454 - cell redox homeostasis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 166 Mm			1 198
+	Mm
		727682 THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00		PRDX1_MOUSE (1-197): 2.88e-99: 287: 74.75
+	Mm
		589514 THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00		PRDX3_MOUSE (2-198): 1.13e-97: 285: 62.94
+	Mm
		139927 THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00		PRDX4_MOUSE (5-198): 3.75e-97: 284: 68.56
+	Hs
		495475 THIO_HUMAN (61-165): 1.71e-36: 123: 34.91		PRDX2_HUMAN (1-198): 1.7e-104: 300: 93.43
+	Hs
		495510 THIO_HUMAN (61-165): 1.71e-36: 123: 34.91		PRDX1_HUMAN (1-197): 9.23e-100: 288: 76.26
+	Hs
		423216 PDIA1_HUMAN (52-166): 3.4e-34: 127: 27.50		PRDX4_HUMAN (5-198): 3.49e-96: 282: 69.59
+	Hs
		1026686 PDIA6_HUMAN (62-165): 2.6e-32: 121: 23.81		PRDX4_HUMAN (5-198): 3.49e-96: 282: 69.59
+	Ss
		852832 THIO_SYNY3 (59-165): 8.35e-39: 129: 31.78		Y755_SYNY3 (6-195): 4.21e-89: 261: 58.12
+	So
		188731 TRXM_SPIOL (14-165): 2.43e-39: 133: 23.03		BAS1_SPIOL (8-195): 3.23e-86: 256: 64.55
+	At
		1227668 TRXX_ARATH (2-165): 2.67e-36: 125: 23.53		BAS1B_ARATH (8-195): 1.45e-87: 260: 63.68
+	Mm
		139705 THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00		PRDX6_MOUSE (4-196): 2.91e-71: 217: 28.64
+	Sc
		611720 TRX2_YEAST (61-154): 7.37e-36: 122: 31.92		TSA1_YEAST (6-198): 4.01e-89: 261: 65.80
+	Os
		1150818 TRXX_ORYSJ (1-165): 1.48e-35: 123: 22.99		BAS1_ORYSJ (5-195): 5.27e-87: 258: 60.62
+	At
		1227667 TRXX_ARATH (2-165): 2.67e-36: 125: 23.53		BAS1A_ARATH (8-195): 3.26e-86: 256: 64.21
+	Sc
		606199 TRX1_YEAST (61-154): 2.56e-35: 120: 37.23		TSA1_YEAST (6-198): 4.01e-89: 261: 65.80
+	Sc
		611752 TRX2_YEAST (61-154): 7.37e-36: 122: 31.92		TSA2_YEAST (6-198): 5.8e-85: 251: 62.18
+	Sc
		606220 TRX1_YEAST (61-154): 2.56e-35: 120: 37.23		TSA2_YEAST (6-198): 5.8e-85: 251: 62.18
+	Ss
		852787 THIO_SYNY3 (59-165): 8.35e-39: 129: 31.78		P73348_SYNY3 (5-196): 3.59e-68: 209: 32.32
+	Sc
		630634 TRX3_YEAST (47-164): 7.06e-37: 125: 29.66		PRX1_YEAST (6-198): 1.8e-67: 209: 30.73
+	Dm
		1177773 THIO2_DROME (61-162): 1.4e-36: 123: 37.86		Q7JX87_DROME (7-193): 5.07e-23: 93.6: 32.83