HitPredict

Interactor 1: SHIP1 (P97573)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1)
Gene: Inpp5d

Interactor 2: DOK1 (Q4QQV2)
Docking protein 1 (Downstream of tyrosine kinase 1)
Gene: DOK1

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	12008030, 11970986, 16407976
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0035556 - intracellular signal transduction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1190 Rn			1 480
+	Mm
		956525 SHIP1_MOUSE (1-1190): 0: 902: 96.56		DOK1_MOUSE (1-480): 0: 550: 93.78
+	Hs
		1271564 SHIP1_HUMAN (4-1190): 0: 846: 87.03		DOK1_HUMAN (1-480): 0: 548: 84.20
+	Mm
		1322349 SHIP1_MOUSE (1-1190): 0: 902: 96.56		DOK3_MOUSE (1-446): 1.24e-119: 359: 29.83
+	Mm
		250958 SHIP1_MOUSE (1-1190): 0: 902: 96.56		DOK2_MOUSE (2-415): 6.12e-111: 336: 32.86
+	Hs
		1184734 SHIP1_HUMAN (4-1190): 0: 846: 87.03		DOK3_HUMAN (1-440): 2.07e-114: 347: 30.80
+	Hs
		235093 SHIP1_HUMAN (4-1190): 0: 846: 87.03		DOK2_HUMAN (2-414): 2.23e-112: 339: 34.66
+	Hs
		243154 SH21A_HUMAN (10-104): 6.67e-20: 88.6: 43.16		DOK1_HUMAN (1-480): 0: 548: 84.20