HitPredict

Interactor 1: M4K4 (P97820)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: Map4k4

Interactor 2: MYOME (Q80YT7)
Myomegalin (Phosphodiesterase 4D-interacting protein)
Gene: Pde4dip

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1233 Mm			1 2224
+	Mm
		949352 TNIK_MOUSE (1-1233): 0: 1067: 62.08		MYOME_MOUSE (1-2224): 0: 695: 100.00
+	Mm
		1194559 MINK1_MOUSE (1-1233): 0: 1050: 59.16		MYOME_MOUSE (1-2224): 0: 695: 100.00
+	Hs
		1138340 TNIK_HUMAN (1-1233): 0: 1045: 60.54		MYOME_HUMAN (1-2224): 5.46e-171: 584: 73.35
+	Mm
		93424 TNIK_MOUSE (1-1233): 0: 1067: 62.08		E9Q3P4_MOUSE (661-2214): 1.37e-31: 138: 8.85
+	Mm
		949273 TNIK_MOUSE (1-1233): 0: 1067: 62.08		Q155P7_MOUSE (661-2214): 1.51e-31: 138: 8.85
+	Hs
		1034641 TNIK_HUMAN (1-1233): 0: 1045: 60.54		GOGA4_HUMAN (2-1093): 6.72e-38: 159: 11.34
+	Rn
		871343 AAPK1_RAT (12-558): 1.28e-117: 379: 17.90		MYOME_RAT (1-2224): 3.36e-170: 581: 82.57
+	Hs
		1313528 SIK2_HUMAN (15-826): 1.18e-120: 398: 15.84		CP250_HUMAN (63-2186): 3.42e-78: 291: 10.78
+	Hs
		728513 SIK2_HUMAN (15-826): 1.18e-120: 398: 15.84		MYH11_HUMAN (1159-2211): 1.5e-38: 161: 9.81
+	Hs
		725242 SIK2_HUMAN (15-826): 1.18e-120: 398: 15.84		MYH10_HUMAN (1220-2207): 2.37e-32: 140: 8.68
+	Rn
		100237 AAPK1_RAT (12-558): 1.28e-117: 379: 17.90		F7FF45_RAT (527-2032): 5.97e-36: 152: 11.07
+	Hs
		725010 SIK2_HUMAN (15-826): 1.18e-120: 398: 15.84		MYH9_HUMAN (1285-2194): 5.31e-30: 133: 9.43
+	Hs
		725223 MARK4_HUMAN (2-669): 3.65e-118: 386: 15.77		MYH10_HUMAN (1220-2207): 2.37e-32: 140: 8.68
+	Rn
		871335 AAPK1_RAT (12-558): 1.28e-117: 379: 17.90		MYH10_RAT (1220-2213): 8.7e-34: 145: 8.52
+	Hs
		724967 MARK4_HUMAN (2-669): 3.65e-118: 386: 15.77		MYH9_HUMAN (1285-2194): 5.31e-30: 133: 9.43
+	Rn
		871291 AAPK1_RAT (12-558): 1.28e-117: 379: 17.90		MYH9_RAT (1034-1889): 8.4e-20: 99.6: 9.59
+	Rn
		102485 AAPK1_RAT (12-558): 1.28e-117: 379: 17.90		G3V6P7_RAT (1004-1984): 9.17e-18: 93: 9.08
+	Hs
		522546 STK3_HUMAN (4-479): 6.79e-118: 377: 29.66		MYH1_HUMAN (1574-2192): 8.05e-15: 83: 10.90
+	Hs
		502912 STK3_HUMAN (4-479): 6.79e-118: 377: 29.66		MYH3_HUMAN (832-1506): 9.14e-11: 69.9: 11.29
+	Hs
		522610 STK3_HUMAN (4-479): 6.79e-118: 377: 29.66		MYH7_HUMAN (6-357): 7.79e-10: 66.9: 11.60