Protein: MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1)

Gene: MUL1
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q969V5

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000266 - mitochondrial fission
GO:0002039 - p53 binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982271

UB2D2
Ubiquitin-conjugating enzyme E2 D2

6

20

Small-scale

0.950

High

906731

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.924

High

957154

UB2D3
Ubiquitin-conjugating enzyme E2 D3

4

20

Small-scale

0.896

High

1381175

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

20

Small-scale

0.852

High

909364

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.800

High

1381412

UB2D4
Ubiquitin-conjugating enzyme E2 D4

2

20

Small-scale

0.800

High

1381381

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

14

Small-scale

0.778

High

993696

UBC9
SUMO-conjugating enzyme UBC9

1

20

Small-scale

0.715

High

508390

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

Small-scale

0.710

High

414359

P53
Cellular tumor antigen p53

4

6

Small-scale

0.707

High

1365951

APBP2
Amyloid protein-binding protein 2

4

5

High-throughput

0.703

High

168555

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

High-throughput

0.698

High

1218738

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1381384

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1242888

S39A4
Zinc transporter ZIP4

4

2

High-throughput

0.691

High

251242

RNBP6
Ran-binding protein 6

3

4

High-throughput

0.662

High

1381401

SCN3B
Sodium channel regulatory subunit beta-3

3

1

High-throughput

0.662

High

1381416

5MP1
eIF5-mimic protein 1

3

4

High-throughput

0.662

High

883305

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

20

Small-scale

0.647

High

957807

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1154282

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

Small-scale

0.647

High

1258790

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

20

Small-scale

0.647

High

828424

PEX19
Peroxisomal biogenesis factor 19

3

0

High-throughput

0.638

High

1381402

ERAP1
Endoplasmic reticulum aminopeptidase 1

2

3

High-throughput

0.628

High

1381410

TRHDE
Thyrotropin-releasing hormone-degrading ectoenzyme

2

2

High-throughput

0.628

High

952454

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

Small-scale

0.621

High

995999

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.621

High

1381388

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

Small-scale

0.621

High

1197850

S39AC
Zinc transporter ZIP12

3

2

High-throughput

0.604

High

248924

GSDME
Gasdermin-E

2

0

High-throughput

0.602

High

279198

ULK1
Serine/threonine-protein kinase ULK1

1

9

Small-scale

0.578

High

728370

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.578

High

273697

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

1

High-throughput

0.574

High

1156942

CNGA3
Cyclic nucleotide-gated channel alpha-3

2

3

High-throughput

0.574

High

1254228

TBCD9
TBC1 domain family member 9

2

2

High-throughput

0.574

High

1381393

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

12

High-throughput

0.573

High

186784

P73
Tumor protein p73

1

6

Small-scale

0.561

High

1292856

STING
Stimulator of interferon genes protein

1

5

Small-scale

0.561

High

950616

KR108
Keratin-associated protein 10-8

2

1

High-throughput

0.553

High

1235724

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

2

5

High-throughput

0.552

High

991392

SUMO1
Small ubiquitin-related modifier 1

1

5

Small-scale

0.550

High

1043163

TAP1
Antigen peptide transporter 1

1

1

High-throughput

0.541

High

174028

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

5

High-throughput

0.536

High

344421

TBCD8
TBC1 domain family member 8

1

2

High-throughput

0.536

High

420648

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.536

High

944535

GEMI4
Gem-associated protein 4

1

2

High-throughput

0.536

High

956966

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.536

High

1022442

IDD
Integral membrane protein DGCR2/IDD

1

3

High-throughput

0.536

High

1310772

CUL9
Cullin-9

1

3

High-throughput

0.536

High

1323641

DOCK4
Dedicator of cytokinesis protein 4

1

1

High-throughput

0.536

High

1381411

SC5A6
Sodium-dependent multivitamin transporter

1

1

High-throughput

0.536

High

1278058

MAVS
Mitochondrial antiviral-signaling protein

1

6

Small-scale

0.515

High

890870

TSC2
Tuberin

1

0

High-throughput

0.513

High

1013528

COG7
Conserved oligomeric Golgi complex subunit 7

1

0

High-throughput

0.513

High

1310290

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1312160

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.513

High

1381385

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.513

High

135669

DNM1L
Dynamin-1-like protein

1

2

Small-scale

0.501

High

213988

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

9

Small-scale

0.501

High

216768

HTRA2
Serine protease HTRA2, mitochondrial

1

14

Small-scale

0.501

High

320748

UBXN7
UBX domain-containing protein 7

1

6

Small-scale

0.501

High

854709

RAGP1
Ran GTPase-activating protein 1

1

8

Small-scale

0.501

High

1381396

EHD1
EH domain-containing protein 1

1

8

Small-scale

0.501

High

777594

PDE6B
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

1

3

High-throughput

0.489

High

1034966

GCYB1
Guanylate cyclase soluble subunit beta-1

1

1

High-throughput

0.489

High

1101615

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

2

High-throughput

0.489

High

1365479

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.489

High

1381394

RBP17
Ran-binding protein 17

1

4

High-throughput

0.489

High

1381397

TTC12
Tetratricopeptide repeat protein 12

1

10

High-throughput

0.489

High

1381400

STK36
Serine/threonine-protein kinase 36

1

6

High-throughput

0.489

High

1381407

IPO11
Importin-11

1

7

High-throughput

0.489

High

1381414

CBPQ
Carboxypeptidase Q

1

1

High-throughput

0.489

High

328102

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

Small-scale

0.479

High

831190

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

934963

TERA
Transitional endoplasmic reticulum ATPase

1

3

Small-scale

0.479

High

1090840

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1366500

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

1369460

TANK
TRAF family member-associated NF-kappa-B activator

1

3

Small-scale

0.479

High

1381389

VPS35
Vacuolar protein sorting-associated protein 35

1

1

Small-scale

0.479

High

1381405

ANFY1
Rabankyrin-5

1

1

Small-scale

0.479

High

1381409

HERC5
E3 ISG15--protein ligase HERC5

1

3

Small-scale

0.479

High

271557

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.458

High

1381382

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

Small-scale

0.458

High

1031834

LAT1
Large neutral amino acids transporter small subunit 1

1

2

High-throughput

0.445

High

1155020

ADIPO
Adiponectin

1

2

High-throughput

0.445

High

1258281

SAMC
Mitochondrial S-adenosylmethionine carrier protein

1

6

High-throughput

0.445

High

1337897

ZNT7
Zinc transporter 7

1

2

High-throughput

0.445

High

1381392

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

1

High-throughput

0.445

High

1381403

MTCH1
Mitochondrial carrier homolog 1

1

8

High-throughput

0.445

High

1381415

MTCH2
Mitochondrial carrier homolog 2

1

8

High-throughput

0.445

High

1381395

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

256107

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

1381387

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.426

High

1246099

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

1

High-throughput

0.407

High

1293885

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

1

High-throughput

0.407

High

1349306

TBC15
TBC1 domain family member 15

1

3

High-throughput

0.407

High

1381404

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

3

High-throughput

0.407

High

1381406

DYH17
Dynein axonemal heavy chain 17

1

5

High-throughput

0.407

High

1381390

HAUS7
HAUS augmin-like complex subunit 7

3

0

High-throughput

0.347

High

1239265

ARMC6
Armadillo repeat-containing protein 6

2

0

High-throughput

0.328

High

1360337

ATRIP
ATR-interacting protein

2

0

High-throughput

0.328

High

1329537

IQCF1
IQ domain-containing protein F1

2

0

High-throughput

0.318

High

1381391

REEP2
Receptor expression-enhancing protein 2

2

0

High-throughput

0.316

High

1381386

SAAL1
Protein SAAL1

2

0

High-throughput

0.313

High

281771

VP26A
Vacuolar protein sorting-associated protein 26A

2

0

Small-scale

0.305

High

906330

GPC3
Glypican-3

1

0

High-throughput

0.279

Low

1165407

CC142
Coiled-coil domain-containing protein 142

1

0

High-throughput

0.279

Low

1169075

INSC
Protein inscuteable homolog

1

0

High-throughput

0.279

Low

1381383

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.279

Low

1381398

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.279

Low

1381408

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

1381413

DOP1B
Protein DOP1B

1

0

High-throughput

0.279

Low

1249085

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1308927

S22A9
Organic anion transporter 7

1

0

High-throughput

0.232

Low

1309523

DAA19
Dynein axonemal assembly factor 19

1

0

High-throughput

0.232

Low

1381399

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025