HitPredict

Interactor 1: AP2S (Q00381)
AP-2 complex subunit sigma (Adaptin small chain) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: APS2

Interactor 2: AP2M (Q99186)
AP-2 complex subunit mu (Adaptin medium chain APM4) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: APM4

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	10564262, 16554755
Identification Methods	coimmunoprecipitation, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adap_comp_sub~Clat_adaptor_s
Common GO terms	GO:0006886 - intracellular protein transport GO:0030122 - AP-2 adaptor complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 147 Sc			1 491
+	Hs
		1315736 AP1M2_HUMAN (1-147): 6.51e-46: 155: 16.89		AP1M1_HUMAN (2-490): 7.21e-162: 466: 28.05
+	Hs
		880428 AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00		AP1M1_HUMAN (2-490): 7.21e-162: 466: 28.05
+	Hs
		1299170 AP1S3_HUMAN (3-147): 7.59e-44: 143: 42.76		AP1M1_HUMAN (2-490): 7.21e-162: 466: 28.05
+	Hs
		880423 AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00		AP2M1_HUMAN (1-490): 2.06e-154: 448: 30.52
+	Hs
		880436 AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00		AP1M2_HUMAN (2-490): 1.09e-154: 448: 28.25
+	Hs
		903691 AP1S1_HUMAN (3-147): 4.12e-46: 148: 37.93		AP2M1_HUMAN (1-490): 2.06e-154: 448: 30.52
+	Hs
		903697 AP1S1_HUMAN (3-147): 4.12e-46: 148: 37.93		AP1M2_HUMAN (2-490): 1.09e-154: 448: 28.25
+	Hs
		1287472 AP1S3_HUMAN (3-147): 7.59e-44: 143: 42.76		AP2M1_HUMAN (1-490): 2.06e-154: 448: 30.52
+	Hs
		1299174 AP1S3_HUMAN (3-147): 7.59e-44: 143: 42.76		AP1M2_HUMAN (2-490): 1.09e-154: 448: 28.25
+	Hs
		864097 AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97		AP2M1_HUMAN (1-490): 2.06e-154: 448: 30.52
+	Mm
		915560 AP2S1_MOUSE (3-147): 5.37e-43: 140: 48.97		AP2M1_MOUSE (1-490): 2.06e-154: 448: 30.52
+	Dm
		248304 Q9VDC3_DROME (3-147): 3.36e-43: 141: 48.28		O62530_DROME (1-490): 5.33e-150: 436: 31.73
+	Hs
		1267501 AP3S1_HUMAN (3-147): 8.28e-48: 154: 37.33		AP3M1_HUMAN (1-490): 5.49e-126: 374: 20.85
+	Hs
		819041 COPZ2_HUMAN (2-140): 4.88e-44: 145: 13.57		COPD_HUMAN (7-489): 2.78e-127: 381: 13.37
+	Hs
		887150 AP3S2_HUMAN (3-147): 5.93e-46: 149: 36.67		AP3M1_HUMAN (1-490): 5.49e-126: 374: 20.85
+	Hs
		864052 AP3S1_HUMAN (3-147): 8.28e-48: 154: 37.33		AP3M2_HUMAN (1-490): 6.25e-120: 359: 21.05
+	Hs
		864041 AP3S2_HUMAN (3-147): 5.93e-46: 149: 36.67		AP3M2_HUMAN (1-490): 6.25e-120: 359: 21.05
+	Hs
		864094 AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97		STON2_HUMAN (124-489): 5.92e-82: 274: 18.83
+	Sc
		745045 AP3S_YEAST (3-145): 1.19e-40: 136: 29.56		AP3M_YEAST (54-490): 5.05e-68: 227: 14.41