HitPredict

Interactor 1: CDK3 (Q00526)
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
Gene: CDK3

Interactor 2: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	28514442, 33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 305 Hs			1 505
+	Hs
		438075 CDK3_HUMAN (1-305): 1.8e-151: 427: 100.00		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		437908 CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431741 CDK3_HUMAN (1-305): 1.8e-151: 427: 100.00		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431549 CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		438077 CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		414683 CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431743 CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		438004 CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		538107 CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71		ENPL_HUMAN (1-504): 0: 597: 35.70
+	Hs
		431662 CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		841223 CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64		H90B4_HUMAN (1-505): 0: 644: 100.00
+	Sp
		383458 CDK1_SCHPO (1-288): 1.98e-129: 371: 63.05		HSP90_SCHPO (1-504): 0: 598: 48.51
+	Sc
		339312 CDK1_YEAST (3-288): 1.32e-131: 377: 63.92		HSP82_YEAST (1-504): 0: 585: 45.53
+	Ca
		793050 CDK1_CANAL (1-286): 3e-130: 374: 66.78		HSP90_CANAL (1-504): 0: 586: 44.48
+	Sc
		339406 CDK1_YEAST (3-288): 1.32e-131: 377: 63.92		HSC82_YEAST (1-504): 0: 582: 44.66
+	Sc
		365744 PHO85_YEAST (3-290): 9.48e-130: 373: 54.21		HSP82_YEAST (1-504): 0: 585: 45.53
+	Sc
		543138 PHO85_YEAST (3-290): 9.48e-130: 373: 54.21		HSC82_YEAST (1-504): 0: 582: 44.66
+	Hs
		841224 CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64		H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87