HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: CD5R1 (Q15078)
Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]
Gene: CDK5R1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.990

The method score is based on:

Property Details
Experiments 26186194, 28514442, 25331900, 26264872, 33961781, 16029324, 17036052, 28637746, 10604467, 11389014, 31319193, 11583627, 17591690, 22654103, 17762160, 23602568, 20133653, 21220307, 15689152, 23543736
Identification Methods affinity chromatography technology, pull down, enzymatic study, fluorescent resonance energy transfer, x-ray crystallography, ion exchange chromatography, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDK5_activator~Pkinase
Common GO terms GO:0000226 - microtubule cytoskeleton organization
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001764 - neuron migration
GO:0004672 - protein kinase activity
GO:0005634 - nucleus
and 28 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 292
Hs

1 307
+ Hs
+ Hs
+ Mm
+ Rn
+ Hs
+ Dm
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024