Protein: UBP42
Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42)

Gene: UBP42, USP42
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9H9J4

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

222530

PLRG1
Pleiotropic regulator 1

1

8

High-throughput

0.691

High

1414865

WDR18
WD repeat-containing protein 18

1

9

High-throughput

0.691

High

508652

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

1239670

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

2

High-throughput

0.628

High

1387566

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.618

High

230111

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

2

0

High-throughput

0.602

High

658412

RS3
Small ribosomal subunit protein uS3

2

1

High-throughput

0.601

High

414645

P53
Cellular tumor antigen p53

1

1

Small-scale

0.596

High

138770

IMA4
Importin subunit alpha-4

1

3

High-throughput

0.536

High

191810

MAGB2
Melanoma-associated antigen B2

1

2

High-throughput

0.536

High

287142

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

7

High-throughput

0.536

High

343055

HERC2
E3 ubiquitin-protein ligase HERC2

1

4

High-throughput

0.536

High

985892

RL11
Large ribosomal subunit protein uL5

1

1

High-throughput

0.536

High

1030694

ANK2
Ankyrin-2

1

2

High-throughput

0.536

High

1062117

SRSF4
Serine/arginine-rich splicing factor 4

1

2

High-throughput

0.536

High

1130979

BMS1
Ribosome biogenesis protein BMS1 homolog

1

1

High-throughput

0.536

High

1145381

RNPS1
RNA-binding protein with serine-rich domain 1

1

2

High-throughput

0.536

High

1197092

AMOT
Angiomotin

1

6

High-throughput

0.536

High

1369775

RAD50
DNA repair protein RAD50

1

5

High-throughput

0.536

High

1402309

RANB9
Ran-binding protein 9

1

5

High-throughput

0.536

High

1437140

TEX10
Testis-expressed protein 10

1

1

High-throughput

0.536

High

1437145

DIM1
Dimethyladenosine transferase

1

2

High-throughput

0.536

High

1437147

SRRM2
Serine/arginine repetitive matrix protein 2

1

3

High-throughput

0.536

High

271296

CPNE3
Copine-3

1

0

High-throughput

0.513

High

367614

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.513

High

1011718

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.513

High

1418885

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.513

High

1435224

RIOX1
Ribosomal oxygenase 1

1

0

High-throughput

0.513

High

1437141

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

374938

RASH
GTPase HRas

1

2

Small-scale

0.501

High

1012619

RT34
Small ribosomal subunit protein mS34

1

1

High-throughput

0.489

High

1323620

LRC47
Leucine-rich repeat-containing protein 47

1

2

High-throughput

0.489

High

1435108

YTDC2
3'-5' RNA helicase YTHDC2

1

8

High-throughput

0.489

High

1279407

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

1

High-throughput

0.481

High

170359

AURKA
Aurora kinase A

1

4

Small-scale

0.479

High

373177

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

691443

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

703066

DPOD1
DNA polymerase delta catalytic subunit

1

1

High-throughput

0.479

High

773029

MYH9
Myosin-9

1

2

High-throughput

0.479

High

790096

ZEB1
Zinc finger E-box-binding homeobox 1

1

2

Small-scale

0.479

High

905157

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

980346

H4
Histone H4

1

4

High-throughput

0.479

High

1005108

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1028400

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.479

High

1033782

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1045781

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

1137527

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1146479

KS6A2
Ribosomal protein S6 kinase alpha-2

1

3

High-throughput

0.479

High

1155783

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

1163214

H2B2E
Histone H2B type 2-E

1

15

Small-scale

0.479

High

1250663

BCOR
BCL-6 corepressor

1

2

High-throughput

0.479

High

1276808

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1412817

PCGF1
Polycomb group RING finger protein 1

1

10

High-throughput

0.479

High

1437144

ALK
ALK tyrosine kinase receptor

1

2

High-throughput

0.479

High

879475

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

1271228

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

1414962

CP250
Centrosome-associated protein CEP250

1

0

High-throughput

0.458

High

1437137

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

290740

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.445

High

601863

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.445

High

649430

H1T
Histone H1t

1

7

High-throughput

0.445

High

686439

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.445

High

810389

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.445

High

860956

RS10
Small ribosomal subunit protein eS10

1

1

High-throughput

0.445

High

990750

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.445

High

1006723

SRPK2
SRSF protein kinase 2

1

7

High-throughput

0.445

High

1016620

SRSF3
Serine/arginine-rich splicing factor 3

1

3

High-throughput

0.445

High

1037378

H11
Histone H1.1

1

6

High-throughput

0.445

High

1128117

DHX8
ATP-dependent RNA helicase DHX8

1

5

High-throughput

0.445

High

1136859

MO4L2
Mortality factor 4-like protein 2

1

1

High-throughput

0.445

High

1437138

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

1437143

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.445

High

1229088

RNF43
E3 ubiquitin-protein ligase RNF43

1

2

Small-scale

0.437

High

1437142

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

1

2

Small-scale

0.437

High

1437146

RL26L
Ribosomal protein uL24-like

1

2

High-throughput

0.407

High

1348962

ZCH10
Zinc finger CCHC domain-containing protein 10

2

0

High-throughput

0.313

High

256387

RT14
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.279

Low

653575

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.279

Low

1012451

RT21
Small ribosomal subunit protein bS21m

1

0

High-throughput

0.279

Low

1366438

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.279

Low

522295

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

106670

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1437139

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025