HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	33961781, 21163940
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051879 - Hsp90 protein binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 378
+	Hs
		625464 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		414935 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		841214 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		989677 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Sp
		294078 CDK1_SCHPO (1-290): 7.99e-128: 367: 52.35		CDC37_SCHPO (2-355): 2.73e-87: 273: 17.35
+	Sc
		339332 CDK1_YEAST (1-288): 1.39e-123: 356: 55.44		CDC37_YEAST (2-320): 1.81e-73: 238: 18.34