HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: CCNI2 (Q6ZMN8)
Cyclin-I2
Gene: CCNI2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 369
+	Hs
		538471 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCNB1_HUMAN (1-365): 4.93e-105: 317: 16.01
+	Hs
		538521 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		CCNB1_HUMAN (1-365): 4.93e-105: 317: 16.01
+	Hs
		303829 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCNB2_HUMAN (1-361): 3.34e-99: 301: 14.82
+	Hs
		624539 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCNE1_HUMAN (3-362): 1.2e-89: 277: 16.76
+	Hs
		624573 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		CCNE1_HUMAN (3-362): 1.2e-89: 277: 16.76
+	Hs
		590125 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCNA2_HUMAN (20-365): 9.49e-87: 270: 19.06
+	Hs
		625350 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCNA1_HUMAN (92-365): 7.96e-85: 266: 16.00
+	Hs
		590162 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		CCNA2_HUMAN (20-365): 9.49e-87: 270: 19.06
+	Xl
		193809 CDK2_XENLA (1-292): 1.16e-142: 404: 59.73		CCNE3_XENLA (6-351): 2.87e-84: 263: 15.23
+	Rn
		70081 Q6P751_RAT (1-292): 2.27e-143: 406: 59.73		B1WC54_RAT (3-367): 7.46e-83: 259: 15.18
+	Hs
		625423 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCNI_HUMAN (112-358): 1.07e-81: 255: 44.05
+	Hs
		625156 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCND3_HUMAN (99-368): 1.79e-77: 242: 19.41
+	Hs
		625253 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCNG1_HUMAN (146-362): 1.91e-74: 234: 27.52
+	Rn
		981205 Q6P751_RAT (1-292): 2.27e-143: 406: 59.73		CCND2_RAT (102-352): 5.12e-66: 212: 20.53
+	Hs
		625155 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCND2_HUMAN (143-352): 2.25e-17: 83.3: 22.12
+	Hs
		331629 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCNE2_HUMAN (144-330): 2.52e-16: 81.7: 24.74
+	Hs
		625523 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		Q8WUE3_HUMAN (144-330): 2.09e-16: 81.7: 24.74
+	Hs
		610197 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CCNO_HUMAN (85-314): 2.12e-15: 78.3: 23.63
+	Hs
		331637 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		CCNE2_HUMAN (144-330): 2.52e-16: 81.7: 24.74
+	Hs
		610205 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		CCNO_HUMAN (85-314): 2.12e-15: 78.3: 23.63