HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29395067
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 669
+	Mm
		829610 CDK5_MOUSE (1-292): 9.13e-139: 394: 99.66		TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67
+	Hs
		989715 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		415112 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		LZTS1_HUMAN (26-653): 2.54e-34: 140: 35.06
+	Hs
		522542 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH1_HUMAN (152-661): 8.43e-14: 77.4: 8.93
+	Hs
		960128 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH2_HUMAN (153-667): 3.25e-13: 75.4: 9.83
+	Hs
		960129 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH13_HUMAN (161-669): 3.57e-13: 75.4: 11.94
+	Hs
		625530 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		502908 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH3_HUMAN (321-655): 9.39e-13: 74: 14.93
+	Hs
		625446 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77
+	Hs
		528401 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		MYH8_HUMAN (196-572): 6.41e-09: 61.6: 9.26
+	Hs
		625177 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79
+	Hs
		528368 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH6_HUMAN (140-554): 2.32e-09: 63.1: 9.14
+	Hs
		528405 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH8_HUMAN (196-572): 6.41e-09: 61.6: 9.26
+	Hs
		522604 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		MYH7_HUMAN (140-540): 9.01e-09: 61.2: 9.45
+	Hs
		148286 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		725114 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79
+	Hs
		61854 CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94		CC88B_HUMAN (60-668): 4.55e-16: 84.7: 12.48