HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: SPDE1 (Q8NFV5)
Speedy protein E1 (Williams-Beuren syndrome chromosomal region 19 protein)
Gene: SPDYE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	15574121
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Spy1
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 336
+	Hs
		625518 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		SPDE1_HUMAN (1-336): 0: 554: 100.00
+	Hs
		414999 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		SPDE1_HUMAN (1-336): 0: 554: 100.00
+	Hs
		625484 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		SPDYC_HUMAN (153-332): 6.24e-54: 179: 32.60
+	Xl
		724514 CDK1A_XENLA (1-289): 5.63e-134: 383: 56.01		SPD1A_XENLA (119-332): 6.46e-62: 201: 33.95
+	Xl
		621606 CDK1B_XENLA (1-289): 9.37e-133: 380: 55.33		SPD1A_XENLA (119-332): 6.46e-62: 201: 33.95
+	Hs
		625485 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		414951 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		SPDYC_HUMAN (153-332): 6.24e-54: 179: 32.60
+	Hs
		960292 CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		414952 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		960374 CDK16_HUMAN (1-286): 1.11e-115: 343: 57.99		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		63992 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		64006 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		625476 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		SPDE7_HUMAN (33-110): 1.34e-21: 93: 53.66
+	Hs
		64007 CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		63987 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		414944 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		SPDE7_HUMAN (33-110): 1.34e-21: 93: 53.66
+	Hs
		64008 CDK16_HUMAN (1-286): 1.11e-115: 343: 57.99		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84