HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: FZR1 (Q9UM11)
Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1)
Gene: FZR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	23589330, 18818692, 22654103
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 496
+	Dm
		618423 CDK1_DROME (1-287): 4.06e-130: 373: 56.40		Q9W4H9_DROME (4-496): 4.54e-116: 351: 68.15
+	Sc
		339758 CDK1_YEAST (1-288): 1.39e-123: 356: 55.44		CDH1_YEAST (44-496): 7.57e-103: 320: 37.81
+	Hs
		625543 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		FBXW7_HUMAN (87-424): 1.7e-71: 242: 18.68
+	Hs
		415016 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		FBXW7_HUMAN (87-424): 1.7e-71: 242: 18.68
+	Hs
		625202 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		LIS1_HUMAN (309-495): 7.12e-53: 185: 19.68
+	Hs
		414806 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		LIS1_HUMAN (309-495): 7.12e-53: 185: 19.68
+	Sc
		339740 CDK1_YEAST (1-288): 1.39e-123: 356: 55.44		AMA1_YEAST (144-474): 4.63e-42: 160: 33.25
+	Hs
		625637 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		FZR1_HUMAN (319-495): 6.65e-25: 109: 18.68
+	Hs
		415103 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		FZR1_HUMAN (319-495): 6.65e-25: 109: 18.68
+	At
		621673 CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82		FZR2_ARATH (319-495): 7.11e-20: 94.2: 22.22
+	At
		621679 CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82		FZR3_ARATH (315-495): 1.15e-19: 93.5: 18.48
+	At
		621683 CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82		FZR1_ARATH (319-495): 8.99e-18: 87.7: 21.67
+	Hs
		625397 CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39		CDC20_HUMAN (395-494): 7.34e-10: 63: 16.67
+	Hs
		414894 CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01		CDC20_HUMAN (395-494): 7.34e-10: 63: 16.67
+	Sc
		339473 CDK1_YEAST (1-288): 1.39e-123: 356: 55.44		CDC20_YEAST (319-488): 5.34e-14: 76.2: 18.50
+	Hs
		841208 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		TAF5_HUMAN (232-494): 4.48e-09: 60.8: 23.02