Protein: STX1A
Syntaxin-1A (Neuron-specific antigen HPC-1)

Gene: STX1A
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q16623

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0001956 - positive regulation of neurotransmitter secretion
GO:0005484 - SNAP receptor activity
GO:0005576 - extracellular region
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

989336

VAMP2
Vesicle-associated membrane protein 2

10

20

Small-scale

0.971

High

963424

STXB1
Syntaxin-binding protein 1

9

20

Small-scale

0.963

High

1159575

STX1A
Syntaxin-1A

5

18

Small-scale

0.924

High

1159633

SNAB
Beta-soluble NSF attachment protein

3

20

High-throughput

0.861

High

280213

SC22B
Vesicle-trafficking protein SEC22b

3

20

Small-scale

0.853

High

328672

VAMP5
Vesicle-associated membrane protein 5

3

20

High-throughput

0.845

High

662345

VAMP1
Vesicle-associated membrane protein 1

3

20

Small-scale

0.845

High

165143

CPLX1
Complexin-1

3

2

Small-scale

0.827

High

1159617

SYTL4
Synaptotagmin-like protein 4

2

11

Small-scale

0.806

High

1159608

STXB6
Syntaxin-binding protein 6

2

5

High-throughput

0.789

High

160272

GOSR2
Golgi SNAP receptor complex member 2

2

20

High-throughput

0.783

High

160893

STX16
Syntaxin-16

2

17

High-throughput

0.783

High

189588

STX7
Syntaxin-7

2

18

High-throughput

0.783

High

226044

STX6
Syntaxin-6

2

20

High-throughput

0.783

High

249857

STX10
Syntaxin-10

2

20

High-throughput

0.783

High

278503

VAMP4
Vesicle-associated membrane protein 4

2

20

High-throughput

0.783

High

286659

STX11
Syntaxin-11

2

18

High-throughput

0.783

High

746201

STX2
Syntaxin-2

2

19

High-throughput

0.783

High

1087125

STX4
Syntaxin-4

2

17

High-throughput

0.783

High

1097780

STX5
Syntaxin-5

2

20

High-throughput

0.783

High

1100668

STX3
Syntaxin-3

2

18

High-throughput

0.783

High

1154625

VAMP3
Vesicle-associated membrane protein 3

2

20

High-throughput

0.783

High

1159593

STX12
Syntaxin-12

2

18

High-throughput

0.783

High

1159653

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

20

High-throughput

0.783

High

1159659

STX8
Syntaxin-8

2

20

High-throughput

0.783

High

639135

SYT1
Synaptotagmin-1

2

8

Small-scale

0.778

High

933012

SNAA
Alpha-soluble NSF attachment protein

2

20

Small-scale

0.768

High

954395

SNP25
Synaptosomal-associated protein 25

14

20

Small-scale

0.760

High

124057

SNP23
Synaptosomal-associated protein 23

7

20

Small-scale

0.743

High

1159628

VAMP8
Vesicle-associated membrane protein 8

1

20

Small-scale

0.724

High

821109

TXLNA
Alpha-taxilin

4

8

Small-scale

0.696

High

343380

SNP29
Synaptosomal-associated protein 29

4

20

Small-scale

0.688

High

720390

SC6A1
Sodium- and chloride-dependent GABA transporter 1

3

15

Small-scale

0.667

High

124362

HAX1
HCLS1-associated protein X-1

3

1

High-throughput

0.656

High

1159577

DGUOK
Deoxyguanosine kinase, mitochondrial

3

1

High-throughput

0.656

High

1159644

KTU
Protein kintoun

3

1

High-throughput

0.656

High

908014

VAMP7
Vesicle-associated membrane protein 7

1

20

Small-scale

0.647

High

563830

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

Small-scale

0.624

High

1033927

SC6A3
Sodium-dependent dopamine transporter

2

15

Small-scale

0.624

High

164811

UN13B
Protein unc-13 homolog B

1

6

Small-scale

0.621

High

1159626

TSNA1
t-SNARE domain-containing protein 1

1

19

High-throughput

0.621

High

1159587

CPLX2
Complexin-2

1

2

Small-scale

0.618

High

139880

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

2

2

High-throughput

0.606

High

179912

BET1
BET1 homolog

2

20

High-throughput

0.606

High

331473

APOL3
Apolipoprotein L3

2

2

High-throughput

0.606

High

483915

HMOX1
Heme oxygenase 1

2

2

High-throughput

0.606

High

688385

PPLA
Phospholamban

2

1

High-throughput

0.606

High

719065

MIP
Lens fiber major intrinsic protein

2

16

High-throughput

0.606

High

894774

EMD
Emerin

2

2

High-throughput

0.606

High

948843

CD81
CD81 antigen

2

11

High-throughput

0.606

High

949245

MYPR
Myelin proteolipid protein

2

4

High-throughput

0.606

High

1091926

SEC20
Vesicle transport protein SEC20

2

6

High-throughput

0.606

High

1092761

MALL
MAL-like protein

2

2

High-throughput

0.606

High

1107518

GPM6B
Neuronal membrane glycoprotein M6-b

2

4

High-throughput

0.606

High

1159578

AR13B
ADP-ribosylation factor-like protein 13B

2

12

High-throughput

0.606

High

1159582

RTP2
Receptor-transporting protein 2

2

1

High-throughput

0.606

High

1159583

SNP47
Synaptosomal-associated protein 47

2

5

High-throughput

0.606

High

1159585

PLPP4
Phospholipid phosphatase 4

2

5

High-throughput

0.606

High

1159600

EMC5
ER membrane protein complex subunit 5

2

3

High-throughput

0.606

High

1159601

VMA12
Vacuolar ATPase assembly protein VMA12

2

2

High-throughput

0.606

High

1159602

JAGN1
Protein jagunal homolog 1

2

2

High-throughput

0.606

High

1159607

CLC1A
C-type lectin domain family 1 member A

2

1

High-throughput

0.606

High

1159612

BT2A2
Butyrophilin subfamily 2 member A2

2

1

High-throughput

0.606

High

1159615

AQP3
Aquaporin-3

2

11

High-throughput

0.606

High

1159616

FAM3C
Protein FAM3C

2

1

High-throughput

0.606

High

1159623

SC22A
Vesicle-trafficking protein SEC22a

2

20

High-throughput

0.606

High

1159625

RMD2
Regulator of microtubule dynamics protein 2

2

2

High-throughput

0.606

High

1159627

APOL2
Apolipoprotein L2

2

2

High-throughput

0.606

High

1159630

TACAN
Transmembrane protein 120A

2

2

High-throughput

0.606

High

1159647

USE1
Vesicle transport protein USE1

2

6

High-throughput

0.606

High

1159648

NINJ2
Ninjurin-2

2

1

High-throughput

0.606

High

1159652

ABI3
ABI gene family member 3

2

9

High-throughput

0.606

High

1159657

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

2

2

High-throughput

0.606

High

1159660

T3JAM
TRAF3-interacting JNK-activating modulator

2

7

High-throughput

0.606

High

1159664

SERP1
Stress-associated endoplasmic reticulum protein 1

2

3

High-throughput

0.606

High

1159584

STXB5
Syntaxin-binding protein 5

2

16

Small-scale

0.602

High

1159655

NUFP1
FMR1-interacting protein NUFIP1

3

1

High-throughput

0.599

High

333026

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

20

Small-scale

0.595

High

727563

SC6A4
Sodium-dependent serotonin transporter

2

15

Small-scale

0.595

High

1131501

KCNB1
Potassium voltage-gated channel subfamily B member 1

2

2

Small-scale

0.595

High

48192

A0AVG3
t-SNARE domain containing 1

1

16

High-throughput

0.594

High

74162

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

378107

TNFA
Tumor necrosis factor

2

0

High-throughput

0.580

High

928855

LIPR1
Inactive pancreatic lipase-related protein 1

2

0

High-throughput

0.580

High

1158338

CDC37
Hsp90 co-chaperone Cdc37

2

0

High-throughput

0.580

High

1159466

NKG7
Protein NKG7

2

0

High-throughput

0.580

High

1159576

AOC3
Amine oxidase [copper-containing] 3

2

0

High-throughput

0.580

High

1159588

ATRAP
Type-1 angiotensin II receptor-associated protein

2

0

High-throughput

0.580

High

1159589

SNORC
Protein SNORC

2

0

High-throughput

0.580

High

1159594

VSTM4
V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv]

2

0

High-throughput

0.580

High

1159595

NRM
Nurim

2

0

High-throughput

0.580

High

1159596

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

0

High-throughput

0.580

High

1159611

R3GEF
Guanine nucleotide exchange factor for Rab-3A

2

0

High-throughput

0.580

High

1159642

TM100
Transmembrane protein 100

2

0

High-throughput

0.580

High

1159643

EKI2
Ethanolamine kinase 2

2

0

High-throughput

0.580

High

1159645

AIG1
Androgen-induced gene 1 protein

2

0

High-throughput

0.580

High

1159599

TXLNB
Beta-taxilin

2

13

Small-scale

0.565

High

902339

SCNNG
Epithelial sodium channel subunit gamma

1

3

Small-scale

0.561

High

1033358

CDR2
Cerebellar degeneration-related protein 2

2

2

High-throughput

0.558

High

69783

ZN785
Zinc finger protein 785

2

6

High-throughput

0.553

High

209020

CYB5B
Cytochrome b5 type B

2

1

High-throughput

0.553

High

295684

UPK1B
Uroplakin-1b

2

12

High-throughput

0.553

High

327277

ZFPL1
Zinc finger protein-like 1

2

3

High-throughput

0.553

High

506160

UBFL1
Upstream-binding factor 1-like protein 1

2

1

High-throughput

0.553

High

585039

ZN250
Zinc finger protein 250

2

2

High-throughput

0.553

High

636219

MAL
Myelin and lymphocyte protein

2

2

High-throughput

0.553

High

913725

ZN136
Zinc finger protein 136

2

3

High-throughput

0.553

High

1004626

RNF4
E3 ubiquitin-protein ligase RNF4

2

7

High-throughput

0.553

High

1159579

T10IP
Testis-specific protein 10-interacting protein

2

1

High-throughput

0.553

High

1159580

AARD
Alanine- and arginine-rich domain-containing protein

2

1

High-throughput

0.553

High

1159592

ANR46
Ankyrin repeat domain-containing protein 46

2

19

High-throughput

0.553

High

1159597

ZN440
Zinc finger protein 440

2

5

High-throughput

0.553

High

1159603

SERP2
Stress-associated endoplasmic reticulum protein 2

2

3

High-throughput

0.553

High

1159604

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

2

High-throughput

0.553

High

1159605

ZN441
Zinc finger protein 441

2

1

High-throughput

0.553

High

1159606

ZN557
Zinc finger protein 557

2

4

High-throughput

0.553

High

1159614

GIMA1
GTPase IMAP family member 1

2

3

High-throughput

0.553

High

1159618

ZN707
Zinc finger protein 707

2

5

High-throughput

0.553

High

1159620

GIMA5
GTPase IMAP family member 5

2

3

High-throughput

0.553

High

1159624

ZN479
Zinc finger protein 479

2

2

High-throughput

0.553

High

1159629

KIFC3
Kinesin-like protein KIFC3

2

2

High-throughput

0.553

High

1159639

ZN696
Zinc finger protein 696

2

4

High-throughput

0.553

High

1159650

TM14C
Transmembrane protein 14C

2

2

High-throughput

0.553

High

1159658

ZN490
Zinc finger protein 490

2

6

High-throughput

0.553

High

1159661

ZN835
Zinc finger protein 835

2

1

High-throughput

0.553

High

1159663

DDX49
Probable ATP-dependent RNA helicase DDX49

2

1

High-throughput

0.553

High

474703

VIME
Vimentin

1

1

High-throughput

0.541

High

681387

PSA3
Proteasome subunit alpha type-3

1

3

High-throughput

0.541

High

1159590

DPP8
Dipeptidyl peptidase 8

1

2

High-throughput

0.515

High

272668

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

2

Small-scale

0.512

High

583081

VATB1
V-type proton ATPase subunit B, kidney isoform

1

2

Small-scale

0.501

High

1025465

CDK5
Cyclin-dependent kinase 5

1

2

Small-scale

0.501

High

1159634

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

3

Small-scale

0.501

High

1159635

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

13

Small-scale

0.501

High

1159651

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

13

Small-scale

0.501

High

791423

SYUA
Alpha-synuclein

1

4

Small-scale

0.500

High

993597

UBC9
SUMO-conjugating enzyme UBC9

1

6

High-throughput

0.481

High

1115685

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.481

High

663631

SC6A2
Sodium-dependent noradrenaline transporter

1

15

Small-scale

0.479

High

788530

SCNNA
Epithelial sodium channel subunit alpha

1

3

Small-scale

0.479

High

870445

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

15

Small-scale

0.479

High

902322

SCNNB
Epithelial sodium channel subunit beta

1

3

Small-scale

0.479

High

906888

GPM6A
Neuronal membrane glycoprotein M6-a

1

4

High-throughput

0.479

High

967763

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

High-throughput

0.479

High

1159619

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

1159649

VAPA
Vesicle-associated membrane protein-associated protein A

1

20

Small-scale

0.479

High

1159662

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

15

Small-scale

0.479

High

1159591

Q7KZS0
SUMO-conjugating enzyme UBC9

1

6

High-throughput

0.470

High

1159636

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.460

High

469488

SYPH
Synaptophysin

1

0

Small-scale

0.458

High

1028220

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.458

High

1159609

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1159640

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

843596

HD
Huntingtin

1

7

High-throughput

0.445

High

960370

SMS
Somatostatin

1

1

Small-scale

0.445

High

107804

SUMO5
Small ubiquitin-related modifier 5

1

0

High-throughput

0.438

High

106011

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1159598

FAM9C
Protein FAM9C

1

1

High-throughput

0.437

High

217096

MS18B
Protein Mis18-beta

3

0

High-throughput

0.342

High

599941

ZNF12
Zinc finger protein 12

2

0

High-throughput

0.316

High

1159581

TM128
Transmembrane protein 128

2

0

High-throughput

0.316

High

1159610

TM254
Transmembrane protein 254

2

0

High-throughput

0.316

High

1159613

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

2

0

High-throughput

0.316

High

1159621

CKLF7
CKLF-like MARVEL transmembrane domain-containing protein 7

2

0

High-throughput

0.316

High

1159622

TM41A
Transmembrane protein 41A

2

0

High-throughput

0.316

High

1159631

SMIM3
Small integral membrane protein 3

2

0

High-throughput

0.316

High

1159632

TM222
Transmembrane protein 222

2

0

High-throughput

0.316

High

1159637

TMM60
Transmembrane protein 60

2

0

High-throughput

0.316

High

1159646

CLN6
Ceroid-lipofuscinosis neuronal protein 6

2

0

High-throughput

0.316

High

1159654

PGAP2
Acyltransferase PGAP2

2

0

High-throughput

0.316

High

1159656

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.316

High

161669

TRDMT
tRNA

1

0

High-throughput

0.282

High

1159638

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

High-throughput

0.282

High

516263

DWORF
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF

1

0

High-throughput

0.268

Low

1159586

GOLM2
Protein GOLM2

1

0

High-throughput

0.251

Low

1159641

C1GLT
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025