HitPredict

Interactor 1: CLH1 (Q00610)
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
Gene: CLTC

Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.729

Property	Details
Experiments	26496610, 28739485, 11278436, 11799118, 19798056, 16137687
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0030136 - clathrin-coated vesicle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1675 Hs			1 1038
+	Mm
		222849 CLH1_MOUSE (1-1675): 0: 3131: 99.88		ACK1_MOUSE (1-1038): 0: 793: 92.70
+	Hs
		522915 CLH1_HUMAN (1-1675): 0: 3132: 100.00		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		412135 CLH1_HUMAN (1-1675): 0: 3132: 100.00		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		960790 CLH1_HUMAN (1-1675): 0: 3132: 100.00		FAK2_HUMAN (49-624): 1.48e-117: 387: 26.22
+	Hs
		665391 CLH1_HUMAN (1-1675): 0: 3132: 100.00		EPHA3_HUMAN (109-456): 3.37e-117: 386: 30.34
+	Hs
		338288 CLH1_HUMAN (1-1675): 0: 3132: 100.00		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Hs
		960776 CLH1_HUMAN (1-1675): 0: 3132: 100.00		TNK1_HUMAN (732-1029): 5.75e-10: 65.2: 22.13
+	Hs
		338174 CLH2_HUMAN (1-1634): 0: 2869: 85.01		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58