Protein: OTU1
Ubiquitin thioesterase OTU1 (EC 3.4.19.12) (OTU domain-containing protein 1)

Gene: OTU1
Organism: Saccharomyces cerevisiae S288C
Interactions: 72
UniProt ID: P43558

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006355 - regulation of DNA-templated transcription
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

679808

CDC48
Cell division control protein 48

11

2

Small-scale

0.977

High

509604

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

3

14

Small-scale

0.862

High

524304

HSP71
Heat shock protein SSA1

3

4

High-throughput

0.650

High

757887

UBX1
UBX domain-containing protein 1

2

1

Small-scale

0.632

High

849719

UFD2
E4 ubiquitin-protein ligase UFD2

2

1

Small-scale

0.632

High

545289

SSB1
Ribosome-associated molecular chaperone SSB1

3

4

High-throughput

0.624

High

436448

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

High-throughput

0.618

High

509905

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

3

High-throughput

0.618

High

849715

OTU1
Ubiquitin thioesterase OTU1

1

7

High-throughput

0.618

High

779952

DOA1
Protein DOA1

1

2

Small-scale

0.573

High

382167

H4
Histone H4

2

1

High-throughput

0.571

High

526979

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.571

High

819058

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.571

High

754437

NPL4
Nuclear protein localization protein 4

1

1

Small-scale

0.561

High

849717

UFD1
Ubiquitin fusion degradation protein 1

1

1

Small-scale

0.561

High

849723

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

3

Small-scale

0.550

High

822220

SECU
Securin

1

0

Small-scale

0.480

High

417130

VDAC1
Non-selective voltage-gated ion channel 1

1

2

High-throughput

0.479

High

455578

SYSC
Serine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

512101

RS4A
Small ribosomal subunit protein eS4A

1

2

High-throughput

0.479

High

531349

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.479

High

570056

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

579594

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.479

High

598881

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

1

High-throughput

0.479

High

655583

TKT1
Transketolase 1

1

1

High-throughput

0.479

High

674689

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

707415

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

760286

BMH2
Protein BMH2

1

2

High-throughput

0.479

High

760600

TSA1
Peroxiredoxin TSA1

1

3

High-throughput

0.479

High

764193

SPT23
Protein SPT23

1

5

Small-scale

0.479

High

775975

TCTP
Translationally-controlled tumor protein homolog

1

1

High-throughput

0.479

High

802563

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

849720

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

849721

COFI
Cofilin

1

1

High-throughput

0.479

High

849722

TSA2
Peroxiredoxin TSA2

1

3

High-throughput

0.479

High

849725

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

450607

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.458

High

454114

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.458

High

724339

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.458

High

815731

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

849724

HOSM
Homocitrate synthase, mitochondrial

1

0

High-throughput

0.458

High

849718

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.457

High

394668

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

741808

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

433704

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

434038

RL33A
Large ribosomal subunit protein eL33A

1

3

High-throughput

0.437

High

434394

RL15A
Large ribosomal subunit protein eL15A

1

2

High-throughput

0.437

High

435589

RS9B
Small ribosomal subunit protein uS4B

1

3

High-throughput

0.437

High

504274

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

513072

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

513517

RL1A
Large ribosomal subunit protein uL1A

1

3

High-throughput

0.437

High

513880

RS11B
Small ribosomal subunit protein uS17B

1

2

High-throughput

0.437

High

585301

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.437

High

597492

EF3A
Elongation factor 3A

1

1

High-throughput

0.437

High

613596

ADT2
ADP,ATP carrier protein 2

1

3

High-throughput

0.437

High

661652

MPCP
Mitochondrial phosphate carrier protein

1

4

High-throughput

0.437

High

672682

BPH1
Beige protein homolog 1

1

1

High-throughput

0.437

High

689062

RL16A
Large ribosomal subunit protein uL13A

1

3

High-throughput

0.437

High

689236

RL16B
Large ribosomal subunit protein uL13B

1

3

High-throughput

0.437

High

734134

EF2
Elongation factor 2

1

2

High-throughput

0.437

High

737467

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

2

High-throughput

0.437

High

747433

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.437

High

831815

RL33B
Large ribosomal subunit protein eL33B

1

3

High-throughput

0.437

High

849716

RL17B
Large ribosomal subunit protein uL22B

1

2

High-throughput

0.437

High

849726

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.437

High

366054

CBPY
Carboxypeptidase Y

1

0

Small-scale

0.426

High

479267

CDC6
Cell division control protein 6

1

0

High-throughput

0.426

High

836754

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

751093

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

0

Small-scale

0.251

Low

439147

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.249

Low

455510

PMM
Phosphomannomutase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025