HitPredict

Interactor 1: CLH1 (Q00610)
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
Gene: CLTC

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 10692452
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1675 Hs			1 576
+	Hs
		960794 CLH1_HUMAN (1-1675): 0: 3132: 100.00		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Rn
		291386 CLH1_RAT (1-1675): 0: 3123: 99.76		EPN1_RAT (1-576): 2.54e-91: 293: 94.27
+	Hs
		307526 CLH1_HUMAN (1-1675): 0: 3132: 100.00		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Hs
		203221 CLH1_HUMAN (1-1675): 0: 3132: 100.00		SYNJ1_HUMAN (246-573): 8.14e-20: 96.3: 14.11
+	Hs
		863938 CLH2_HUMAN (1-1634): 0: 2869: 85.01		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Dm
		669592 CLH_DROME (1-1663): 0: 2911: 80.17		Q7KU90_DROME (1-571): 4.4e-58: 209: 31.51
+	At
		1012797 CLAH1_ARATH (6-1636): 0: 2638: 56.38		EPN1_ARATH (2-453): 4.14e-71: 240: 21.26
+	At
		1012719 CLAH2_ARATH (6-1636): 0: 2651: 56.62		EPN2_ARATH (2-574): 1.39e-39: 156: 21.89
+	Sc
		604440 CLH_YEAST (5-1648): 0: 2443: 49.79		ENT3_YEAST (4-358): 3.06e-73: 241: 23.32
+	Sc
		604493 CLH_YEAST (5-1648): 0: 2443: 49.79		ENT1_YEAST (3-228): 6.81e-62: 212: 36.73
+	Sc
		604473 CLH_YEAST (5-1648): 0: 2443: 49.79		ENT2_YEAST (3-538): 7.67e-59: 208: 19.59
+	Sc
		604463 CLH_YEAST (5-1648): 0: 2443: 49.79		ENT5_YEAST (3-384): 8.16e-44: 162: 17.96