Protein: SRS12
Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)

Gene: SRS12, SRSF12
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q8WXF0

Gene Ontology (top 5):
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0000395 - mRNA 5'-splice site recognition
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006593

SRPK2
SRSF protein kinase 2

3

20

High-throughput

0.867

High

472928

RU17
U1 small nuclear ribonucleoprotein 70 kDa

3

18

High-throughput

0.861

High

1111819

TRA2A
Transformer-2 protein homolog alpha

3

20

High-throughput

0.861

High

612717

RL7
Large ribosomal subunit protein uL30

2

6

High-throughput

0.811

High

685658

U2AF2
Splicing factor U2AF 65 kDa subunit

2

20

High-throughput

0.811

High

889625

CLK2
Dual specificity protein kinase CLK2

2

20

High-throughput

0.811

High

889777

CLK3
Dual specificity protein kinase CLK3

2

20

High-throughput

0.811

High

1025396

CDK6
Cyclin-dependent kinase 6

1

6

Small-scale

0.710

High

1360393

SRPK1
SRSF protein kinase 1

1

20

High-throughput

0.710

High

74561

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

20

High-throughput

0.691

High

284191

SRS10
Serine/arginine-rich splicing factor 10

1

20

High-throughput

0.691

High

658304

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.691

High

1009267

PRR3
Proline-rich protein 3

1

4

High-throughput

0.691

High

1016541

SRSF3
Serine/arginine-rich splicing factor 3

1

19

High-throughput

0.691

High

1051503

SRS11
Serine/arginine-rich splicing factor 11

1

10

High-throughput

0.691

High

1061075

SRSF1
Serine/arginine-rich splicing factor 1

1

20

High-throughput

0.691

High

1062062

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

1099459

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

1115856

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

17

High-throughput

0.691

High

1194243

LARP7
La-related protein 7

1

19

High-throughput

0.691

High

1252477

LN28B
Protein lin-28 homolog B

1

20

High-throughput

0.691

High

1360384

LAR4B
La-related protein 4B

1

20

High-throughput

0.691

High

1360400

LN28A
Protein lin-28 homolog A

1

20

High-throughput

0.691

High

1360416

ZN346
Zinc finger protein 346

1

5

High-throughput

0.691

High

1360423

RBMX2
RNA-binding motif protein, X-linked 2

1

20

High-throughput

0.691

High

1290616

ZCH18
Zinc finger CCCH domain-containing protein 18

3

18

High-throughput

0.667

High

1346864

SNIP1
Smad nuclear-interacting protein 1

3

4

High-throughput

0.667

High

1360411

NOL12
Nucleolar protein 12

3

1

High-throughput

0.667

High

1360422

LC7L2
Putative RNA-binding protein Luc7-like 2

3

10

High-throughput

0.667

High

1168539

KNOP1
Lysine-rich nucleolar protein 1

2

1

High-throughput

0.628

High

1314825

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

2

12

High-throughput

0.628

High

961070

MGN
Protein mago nashi homolog

1

6

High-throughput

0.618

High

1134018

ZN638
Zinc finger protein 638

1

10

High-throughput

0.618

High

966678

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

649381

H1T
Histone H1t

2

13

High-throughput

0.574

High

889474

CLK1
Dual specificity protein kinase CLK1

1

20

High-throughput

0.555

High

157673

CTRO
Citron Rho-interacting kinase

1

17

High-throughput

0.553

High

176858

DCLK1
Serine/threonine-protein kinase DCLK1

1

2

High-throughput

0.553

High

245257

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

10

High-throughput

0.553

High

1025577

CDK16
Cyclin-dependent kinase 16

1

5

High-throughput

0.553

High

1129966

MELK
Maternal embryonic leucine zipper kinase

1

6

High-throughput

0.553

High

691288

1433T
14-3-3 protein theta

2

20

High-throughput

0.549

High

730099

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.549

High

1049617

1433F
14-3-3 protein eta

2

20

High-throughput

0.549

High

192617

NUP42
Nucleoporin NUP42

1

2

High-throughput

0.536

High

301136

RL1D1
Ribosomal L1 domain-containing protein 1

1

4

High-throughput

0.536

High

860291

RS9
Small ribosomal subunit protein uS4

1

3

High-throughput

0.536

High

860859

RS10
Small ribosomal subunit protein eS10

1

1

High-throughput

0.536

High

979097

RS6
Small ribosomal subunit protein eS6

1

5

High-throughput

0.536

High

1112111

KRR1
KRR1 small subunit processome component homolog

1

3

High-throughput

0.536

High

1168850

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

6

High-throughput

0.536

High

1213295

RM02
Large ribosomal subunit protein uL2m

1

7

High-throughput

0.536

High

1323944

H2B3B
Histone H2B type 3-B

1

8

High-throughput

0.536

High

1360385

RENT1
Regulator of nonsense transcripts 1

1

15

High-throughput

0.536

High

1360398

UTP23
rRNA-processing protein UTP23 homolog

1

1

High-throughput

0.536

High

243689

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

15

High-throughput

0.515

High

1360397

LLPH
Protein LLP homolog

1

0

High-throughput

0.513

High

1360409

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

1360419

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

191729

MAGB2
Melanoma-associated antigen B2

1

8

High-throughput

0.489

High

502453

H2A1
Histone H2A type 1

1

7

High-throughput

0.489

High

517794

GLI4
Zinc finger protein GLI4

1

1

High-throughput

0.489

High

1356122

THAP3
THAP domain-containing protein 3

1

3

High-throughput

0.489

High

1360410

ZBT47
Zinc finger and BTB domain-containing protein 47

1

1

High-throughput

0.489

High

258164

IF2P
Eukaryotic translation initiation factor 5B

1

3

High-throughput

0.481

High

230553

KIF1C
Kinesin-like protein KIF1C

1

10

High-throughput

0.479

High

248328

HBP1
HMG box-containing protein 1

1

7

High-throughput

0.479

High

252129

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

4

High-throughput

0.479

High

331189

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

406436

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

637934

NF1
Neurofibromin

1

8

High-throughput

0.479

High

719249

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

719357

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

936400

AFAD
Afadin

1

11

High-throughput

0.479

High

937836

FOXA1
Hepatocyte nuclear factor 3-alpha

1

5

High-throughput

0.479

High

941032

HDAC4
Histone deacetylase 4

1

9

High-throughput

0.479

High

960187

RL26
Large ribosomal subunit protein uL24

1

3

High-throughput

0.479

High

1035811

KIF23
Kinesin-like protein KIF23

1

19

High-throughput

0.479

High

1152020

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

1

High-throughput

0.479

High

1234880

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.479

High

1313295

SMC5
Structural maintenance of chromosomes protein 5

1

11

High-throughput

0.479

High

1328882

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

7

High-throughput

0.479

High

1360390

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.479

High

1360391

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

8

High-throughput

0.479

High

1360392

TESK2
Dual specificity testis-specific protein kinase 2

1

2

High-throughput

0.479

High

1360401

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.479

High

1360403

ANLN
Anillin

1

10

High-throughput

0.479

High

1360404

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1360415

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

High-throughput

0.479

High

1360417

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.479

High

1360418

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

1360396

COR1B
Coronin-1B

1

12

High-throughput

0.470

High

1360394

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1360424

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

807512

IF4A3
Eukaryotic initiation factor 4A-III

1

20

High-throughput

0.445

High

1360414

DDX41
Probable ATP-dependent RNA helicase DDX41

1

14

High-throughput

0.445

High

208712

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.437

High

269590

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

6

High-throughput

0.437

High

281384

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.437

High

1065745

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

12

High-throughput

0.437

High

1092469

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

4

High-throughput

0.437

High

1187126

TBC25
TBC1 domain family member 25

1

4

High-throughput

0.437

High

1216079

SPD2A
SH3 and PX domain-containing protein 2A

1

6

High-throughput

0.437

High

1219605

DEN4C
DENN domain-containing protein 4C

1

2

High-throughput

0.437

High

1229896

AN34A
Ankyrin repeat domain-containing protein 34A

1

3

High-throughput

0.437

High

1257027

SYDE1
Rho GTPase-activating protein SYDE1

1

7

High-throughput

0.437

High

1277702

MYCPP
C-myc promoter-binding protein

1

2

High-throughput

0.437

High

1286524

PHLB2
Pleckstrin homology-like domain family B member 2

1

16

High-throughput

0.437

High

1309231

KSR1
Kinase suppressor of Ras 1

1

11

High-throughput

0.437

High

1338087

NAV1
Neuron navigator 1

1

7

High-throughput

0.437

High

1349464

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

1352598

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.437

High

1357396

DEP1B
DEP domain-containing protein 1B

1

5

High-throughput

0.437

High

1360383

ASB11
Ankyrin repeat and SOCS box protein 11

1

4

High-throughput

0.437

High

1360386

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.437

High

1360388

EDC3
Enhancer of mRNA-decapping protein 3

1

2

High-throughput

0.437

High

1360395

F110A
Protein FAM110A

1

1

High-throughput

0.437

High

1360402

KI13B
Kinesin-like protein KIF13B

1

10

High-throughput

0.437

High

1360407

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.437

High

1360408

CING
Cingulin

1

2

High-throughput

0.437

High

1360412

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.437

High

1360413

NGAP
Ras GTPase-activating protein nGAP

1

8

High-throughput

0.437

High

1360420

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.437

High

1360421

GAB2
GRB2-associated-binding protein 2

1

11

High-throughput

0.437

High

1360425

KCTD3
BTB/POZ domain-containing protein KCTD3

1

6

High-throughput

0.437

High

1360387

ZN689
Zinc finger protein 689

1

0

High-throughput

0.279

Low

1360389

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

1360426

LENEP
Lens epithelial cell protein LEP503

1

0

High-throughput

0.279

Low

339097

NADK
NAD kinase

1

0

High-throughput

0.249

Low

1216012

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

0

High-throughput

0.249

Low

1360399

RTKN
Rhotekin

1

0

High-throughput

0.249

Low

1360405

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

1360406

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025