HitPredict

Interactor 1: NFKB2 (Q00653)
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
Gene: NFKB2

Interactor 2: IKBB (Q15653)
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
Gene: NFKBIB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26186194, 28514442, 33961781, 14743216
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Ank_2, Ank_2~Ank_2, Ank_2~Ank_4, Ank~RHD_dimer, Ank_2~RHD_dimer
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006954 - inflammatory response
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 900 Hs			1 356
+	Hs
		639729 NFKB2_HUMAN (1-900): 0: 713: 100.00		IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21
+	Hs
		961363 NFKB2_HUMAN (1-900): 0: 713: 100.00		NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15
+	Hs
		121583 NFKB2_HUMAN (1-900): 0: 713: 100.00		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Mm
		638475 NFKB1_MOUSE (6-881): 0: 603: 41.91		IKBA_MOUSE (7-335): 8.92e-77: 240: 31.07
+	Hs
		587589 NFKB1_HUMAN (6-881): 0: 586: 41.27		IKBB_HUMAN (1-356): 9.91e-80: 249: 100.00
+	Hs
		587427 NFKB1_HUMAN (6-881): 0: 586: 41.27		IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21
+	Mm
		638473 NFKB2_MOUSE (1-900): 0: 727: 91.78		NFKB1_MOUSE (14-140): 5.94e-11: 65.9: 29.46
+	Hs
		121567 NFKB1_HUMAN (6-881): 0: 586: 41.27		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Hs
		595669 NFKB2_HUMAN (1-900): 0: 713: 100.00		BCL3_HUMAN (49-151): 2.25e-12: 69.8: 28.16
+	Hs
		587527 NFKB2_HUMAN (1-900): 0: 713: 100.00		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57
+	Mm
		638435 NFKB1_MOUSE (6-881): 0: 603: 41.91		NFKB1_MOUSE (14-140): 5.94e-11: 65.9: 29.46
+	Hs
		587410 NFKB1_HUMAN (6-881): 0: 586: 41.27		BCL3_HUMAN (49-151): 2.25e-12: 69.8: 28.16
+	Hs
		587408 NFKB1_HUMAN (6-881): 0: 586: 41.27		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57
+	Hs
		587628 NFKB1_HUMAN (6-881): 0: 586: 41.27		ANKH1_HUMAN (6-91): 2.81e-10: 63.8: 16.28
+	Hs
		121586 REL_HUMAN (33-456): 2.67e-112: 359: 33.88		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Dm
		974284 NFKB1_DROME (8-841): 2.36e-117: 382: 22.94		CACT_DROME (147-303): 1.16e-15: 79.8: 23.60
+	Hs
		46907 A0A494C1E9_HUMAN (6-396): 7.9e-124: 386: 52.52		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57
+	Hs
		587543 REL_HUMAN (33-456): 2.67e-112: 359: 33.88		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57