Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2
Interactor 2: UBP7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: USP7
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 0.60 | 0.768 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 27452404, 28196907, 26971997, 29295817, 31647545, 36952348, 17380154, 16402859, 20713061, 16845383, 20816748, 18566590, 16474402, 26460617, 26238070, 24462112, 28406480, 29236775, 17936559, 16943424 and 3 others
more... |
| Identification Methods | pull down, affinity chromatography technology, unspecified method, x-ray crystallography, enzymatic study, classical fluorescence spectroscopy, isothermal titration calorimetry, molecular sieving, anti bait coimmunoprecipitation, fluorescence polarization spectroscopy and 1 others
more... |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0002039 - p53 binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination and 1 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
