Protein: GBB4
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)

Gene: GBB4, GNB4
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q9HAV0

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:0005834 - heterotrimeric G-protein complex
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

887126

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

5

20

Small-scale

0.920

High

837682

GBG4

4

20

Small-scale

0.900

High

929157

GBG3

4

20

Small-scale

0.900

High

391465

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

4

20

Small-scale

0.899

High

444791

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

4

20

Small-scale

0.899

High

926713

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

4

20

Small-scale

0.899

High

929176

GBG5

3

20

Small-scale

0.854

High

926641

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

3

20

High-throughput

0.847

High

815927

MTR1A
Melatonin receptor type 1A

2

8

Small-scale

0.819

High

837704

GBG10

2

20

Small-scale

0.799

High

929145

GBG1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

2

20

Small-scale

0.799

High

1334924

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

2

20

Small-scale

0.799

High

825746

MTR1B
Melatonin receptor type 1B

2

7

Small-scale

0.789

High

1334919

GBG13

2

6

Small-scale

0.778

High

229245

GBG7

2

20

Small-scale

0.767

High

921054

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

15

High-throughput

0.691

High

1053436

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

20

High-throughput

0.691

High

1236604

GP161
G-protein coupled receptor 161

1

6

High-throughput

0.691

High

902497

GBG11

1

20

Small-scale

0.647

High

1334920

GBG12

1

20

Small-scale

0.647

High

964771

GALK2
N-acetylgalactosamine kinase

2

3

High-throughput

0.628

High

150117

GBGT2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

1

20

Small-scale

0.621

High

819560

KCNJ5
G protein-activated inward rectifier potassium channel 4

1

2

High-throughput

0.618

High

149307

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.618

High

429130

ADRB2
Beta-2 adrenergic receptor

1

5

High-throughput

0.618

High

833687

RGS6
Regulator of G-protein signaling 6

1

13

Small-scale

0.618

High

870906

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

8

High-throughput

0.618

High

1032876

PHLP
Phosducin-like protein

1

14

Small-scale

0.618

High

1171776

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.618

High

1334912

ANLN
Anillin

1

7

High-throughput

0.618

High

447294

HXB5
Homeobox protein Hox-B5

2

2

High-throughput

0.611

High

578861

SDC1
Syndecan-1

2

0

High-throughput

0.602

High

370470

ESR1
Estrogen receptor

2

20

Small-scale

0.594

High

1024837

DUS4
Dual specificity protein phosphatase 4

2

2

High-throughput

0.571

High

297136

PKHG5
Pleckstrin homology domain-containing family G member 5

1

16

High-throughput

0.536

High

989726

CDK18
Cyclin-dependent kinase 18

1

5

High-throughput

0.536

High

1021827

TP4A2
Protein tyrosine phosphatase type IVA 2

1

4

High-throughput

0.536

High

1302398

CP2S1
Cytochrome P450 2S1

1

1

High-throughput

0.536

High

1334925

FZD10
Frizzled-10

1

2

High-throughput

0.536

High

527800

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

1334928

SHLB1
Endophilin-B1

1

3

High-throughput

0.515

High

476404

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

High-throughput

0.501

High

890846

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.501

High

877145

CASP6
Caspase-6

1

0

High-throughput

0.493

High

1081608

NTRK3
NT-3 growth factor receptor

1

12

High-throughput

0.489

High

1139179

RSBN1
Lysine-specific demethylase 9

1

2

High-throughput

0.489

High

1333280

PACC1
Proton-activated chloride channel

1

1

High-throughput

0.489

High

124308

DFFA
DNA fragmentation factor subunit alpha

1

1

High-throughput

0.479

High

157141

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.479

High

163306

XPO1
Exportin-1

1

9

High-throughput

0.479

High

168038

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

210290

PRC1
Protein regulator of cytokinesis 1

1

5

High-throughput

0.479

High

228745

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

320228

ERR2
Steroid hormone receptor ERR2

1

20

High-throughput

0.479

High

347932

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

429940

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

436516

RHOC
Rho-related GTP-binding protein RhoC

1

13

High-throughput

0.479

High

529739

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.479

High

545626

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

570076

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

625051

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

7

Small-scale

0.479

High

808943

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.479

High

852628

RND2
Rho-related GTP-binding protein RhoN

1

13

High-throughput

0.479

High

892604

RAC3
Ras-related C3 botulinum toxin substrate 3

1

12

High-throughput

0.479

High

894451

CDC42
Cell division control protein 42 homolog

1

12

High-throughput

0.479

High

897822

ABCE1
ATP-binding cassette sub-family E member 1

1

2

High-throughput

0.479

High

900924

RHOA
Transforming protein RhoA

1

13

High-throughput

0.479

High

915985

RHOB
Rho-related GTP-binding protein RhoB

1

13

High-throughput

0.479

High

925630

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

High-throughput

0.479

High

935255

H31
Histone H3.1

1

8

High-throughput

0.479

High

951353

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

1016870

TFCP2
Alpha-globin transcription factor CP2

1

4

High-throughput

0.479

High

1043234

CUL4A
Cullin-4A

1

20

Small-scale

0.479

High

1057241

KCTD2
BTB/POZ domain-containing protein KCTD2

1

9

Small-scale

0.479

High

1066722

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1076767

RHOH
Rho-related GTP-binding protein RhoH

1

14

High-throughput

0.479

High

1119486

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

6

High-throughput

0.479

High

1164744

ANR12
Ankyrin repeat domain-containing protein 12

1

9

High-throughput

0.479

High

1189703

RD3
Protein RD3

1

1

High-throughput

0.479

High

1218190

CEP97
Centrosomal protein of 97 kDa

1

5

Small-scale

0.479

High

1220396

SKA3
Spindle and kinetochore-associated protein 3

1

1

Small-scale

0.479

High

1235375

KCD17
BTB/POZ domain-containing protein KCTD17

1

9

Small-scale

0.479

High

1256407

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1304014

PFD5
Prefoldin subunit 5

1

11

High-throughput

0.479

High

1315864

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.479

High

1330511

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

1330925

RHOJ
Rho-related GTP-binding protein RhoJ

1

14

High-throughput

0.479

High

1333738

ECT2
Protein ECT2

1

11

High-throughput

0.479

High

1334911

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

1334916

KCTD5
BTB/POZ domain-containing protein KCTD5

1

9

Small-scale

0.479

High

1334921

HDAC6
Histone deacetylase 6

1

11

High-throughput

0.479

High

1334922

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

1334923

FKBPL
FK506-binding protein-like

1

18

High-throughput

0.479

High

1334926

LIMC1
LIM and calponin homology domains-containing protein 1

1

7

High-throughput

0.479

High

1334927

NUDC
Nuclear migration protein nudC

1

16

High-throughput

0.479

High

1334930

ARI1
E3 ubiquitin-protein ligase ARIH1

1

9

High-throughput

0.479

High

1334931

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

2

High-throughput

0.479

High

441778

CFAH
Complement factor H

1

0

Small-scale

0.458

High

583367

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

1334913

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1334914

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

1315361

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.457

High

314923

GNAS3
Neuroendocrine secretory protein 55

1

2

High-throughput

0.445

High

383985

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

10

High-throughput

0.445

High

718212

BMI1
Polycomb complex protein BMI-1

1

13

High-throughput

0.445

High

1047266

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

1236267

CD177
CD177 antigen

1

3

Small-scale

0.445

High

1246436

INADL
InaD-like protein

1

6

High-throughput

0.445

High

309078

KI20A
Kinesin-like protein KIF20A

1

17

High-throughput

0.437

High

1285450

Q96BE0
Heat shock cognate 71 kDa protein

1

17

High-throughput

0.437

High

1291484

TSN17
Tetraspanin-17

1

2

High-throughput

0.437

High

1301918

CCNL2
Cyclin-L2

1

2

High-throughput

0.437

High

1334910

Q9HAV2
Heat shock transcription factor 1

1

3

High-throughput

0.437

High

1334915

OCAD1
OCIA domain-containing protein 1

1

2

High-throughput

0.437

High

1334917

MTCH1
Mitochondrial carrier homolog 1

1

5

High-throughput

0.437

High

1334929

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

20

High-throughput

0.437

High

1318850

ZDHC5
Palmitoyltransferase ZDHHC5

1

6

High-throughput

0.407

High

966292

TFAP4
Transcription factor AP-4

1

0

High-throughput

0.279

Low

1161187

CXB7
Gap junction beta-7 protein

1

0

High-throughput

0.279

Low

1331108

SEHL2
Serine hydrolase-like protein 2

1

0

High-throughput

0.279

Low

1334918

KCND2
Potassium voltage-gated channel subfamily D member 2

1

0

High-throughput

0.279

Low

64265

LRIQ3
Leucine-rich repeat and IQ domain-containing protein 3

1

0

High-throughput

0.249

Low

154526

MEIS2
Homeobox protein Meis2

1

0

High-throughput

0.249

Low

1244222

T185A
Transmembrane protein 185A

1

0

High-throughput

0.249

Low

1263085

MB3L1
Methyl-CpG-binding domain protein 3-like 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024