HitPredict

Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: UB2E2 (Q96LR5)
Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)
Gene: UBE2E2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	24980433, 30017913, 21965653
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 491 Hs			1 201
+	Hs
		962909 MDM2_HUMAN (1-491): 0: 710: 100.00		UB2E3_HUMAN (1-201): 6.37e-85: 251: 79.71
+	Hs
		963034 MDM2_HUMAN (1-491): 0: 710: 100.00		UB2D4_HUMAN (55-200): 9.37e-83: 243: 63.01
+	Hs
		919708 MDM2_HUMAN (1-491): 0: 710: 100.00		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		849309 MDM2_HUMAN (1-491): 0: 710: 100.00		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		851803 MDM2_HUMAN (1-491): 0: 710: 100.00		UB2E1_HUMAN (28-201): 6.5e-80: 238: 89.71
+	Hs
		895778 MDM2_HUMAN (1-491): 0: 710: 100.00		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		828987 MDM2_HUMAN (1-491): 0: 710: 100.00		UBE2A_HUMAN (54-198): 1.67e-70: 212: 35.86
+	Hs
		896417 MDM2_HUMAN (1-491): 0: 710: 100.00		UBE2N_HUMAN (53-200): 2.86e-70: 212: 45.27
+	Mm
		620834 MDM2_MOUSE (1-490): 0: 639: 80.24		UB2D1_MOUSE (55-200): 1.23e-81: 240: 61.64
+	Mm
		620833 MDM2_MOUSE (1-490): 0: 639: 80.24		UB2D3_MOUSE (55-200): 1.28e-80: 238: 63.70
+	Hs
		169270 MDM4_HUMAN (4-489): 0: 531: 32.08		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		169259 MDM4_HUMAN (4-489): 0: 531: 32.08		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		169262 MDM4_HUMAN (4-489): 0: 531: 32.08		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70