HitPredict

Interactor 1: UFO (Q00993)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (Adhesion-related kinase)
Gene: Axl

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18346204
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 888 Mm			1 217
+	Hs
		674385 UFO_HUMAN (1-888): 0: 760: 88.06		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		411613 UFO_HUMAN (1-888): 0: 760: 88.06		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Mm
		70553 UFO_MOUSE (1-888): 0: 771: 100.00		B2RQ57_MOUSE (4-139): 1.52e-20: 91.3: 33.33
+	Hs
		674354 UFO_HUMAN (1-888): 0: 760: 88.06		ABL2_HUMAN (4-139): 9.7e-22: 94.7: 34.04
+	Hs
		522808 UFO_HUMAN (1-888): 0: 760: 88.06		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		665389 EPHA3_HUMAN (70-835): 0: 577: 21.26		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		872610 EPHB1_HUMAN (3-834): 0: 573: 20.93		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		872630 EPHA4_HUMAN (70-830): 0: 573: 21.18		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		337359 EPHA3_HUMAN (70-835): 0: 577: 21.26		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Mm
		337625 EPHA4_MOUSE (70-830): 0: 577: 21.31		ABL1_MOUSE (4-139): 4.43e-22: 95.5: 35.46
+	Hs
		557644 EPHB1_HUMAN (3-834): 0: 573: 20.93		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		789049 EPHA4_HUMAN (70-830): 0: 573: 21.18		ABL2_HUMAN (4-139): 9.7e-22: 94.7: 34.04
+	Hs
		412036 EPHA3_HUMAN (70-835): 0: 577: 21.26		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Mm
		763386 EPHA4_MOUSE (70-830): 0: 577: 21.31		FYN_MOUSE (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		412105 EPHA4_HUMAN (70-830): 0: 573: 21.18		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		522802 EPHA3_HUMAN (70-835): 0: 577: 21.26		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		433602 EPHA3_HUMAN (70-835): 0: 577: 21.26		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Hs
		855777 EPHA4_HUMAN (70-830): 0: 573: 21.18		VAV2_HUMAN (3-56): 6.02e-11: 63.1: 38.18
+	Hs
		522871 EPHA4_HUMAN (70-830): 0: 573: 21.18		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		433662 EPHA4_HUMAN (70-830): 0: 573: 21.18		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39