Protein: GBB
Guanine nucleotide-binding protein subunit beta

Gene: GBB, STE4
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: P18851

Gene Ontology (top 5):
GO:0000749 - response to pheromone triggering conjugation with cellular fusion
GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0001403 - invasive growth in response to glucose limitation
GO:0001965 - G-protein alpha-subunit binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

470733

GPA1
Guanine nucleotide-binding protein alpha-1 subunit

20

20

Small-scale

0.989

High

617367

GBG
Guanine nucleotide-binding protein subunit gamma

12

0

Small-scale

0.927

High

542937

CDC24
Cell division control protein 24

6

7

Small-scale

0.733

High

617416

PLP1
Phosducin-like protein 1

1

16

Small-scale

0.724

High

617381

STE5
Protein STE5

10

0

Small-scale

0.723

High

553940

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.691

High

617377

ARP2
Actin-related protein 2

1

8

High-throughput

0.691

High

617392

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.691

High

617369

FAR1
Cyclin-dependent kinase inhibitor FAR1

3

0

Small-scale

0.651

High

518194

IF4A
ATP-dependent RNA helicase eIF4A

1

12

High-throughput

0.646

High

617404

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.646

High

617408

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.646

High

617415

STE20
Serine/threonine-protein kinase STE20

2

11

Small-scale

0.634

High

617391

AKR1
Palmitoyltransferase AKR1

4

7

Small-scale

0.632

High

617393

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.618

High

617395

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.618

High

617401

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.618

High

617366

GBB
Guanine nucleotide-binding protein subunit beta

1

17

Small-scale

0.618

High

617410

CLA4
Serine/threonine-protein kinase CLA4

1

6

Small-scale

0.618

High

617407

MTR4
ATP-dependent RNA helicase DOB1

1

20

High-throughput

0.595

High

591994

VATB
V-type proton ATPase subunit B

2

8

High-throughput

0.584

High

617375

MAS5
Mitochondrial protein import protein MAS5

2

14

High-throughput

0.584

High

617368

HSP60
Heat shock protein 60, mitochondrial

1

20

High-throughput

0.578

High

617394

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.578

High

617413

ACT
Actin

1

7

High-throughput

0.578

High

617396

RSP5
E3 ubiquitin-protein ligase RSP5

1

3

Small-scale

0.561

High

617417

PLP2
Phosducin-like protein 2

1

15

Small-scale

0.561

High

94530

STE2
Pheromone alpha factor receptor

2

0

Small-scale

0.559

High

617373

STE50
Protein STE50

2

0

Small-scale

0.559

High

617371

KC11
Casein kinase I homolog 1

1

13

Small-scale

0.552

High

617400

SSB2
Ribosome-associated molecular chaperone SSB2

2

17

High-throughput

0.552

High

617388

YHJ3
Uncharacterized protein YHR033W

1

3

High-throughput

0.536

High

617418

AHA1
Hsp90 co-chaperone AHA1

1

1

High-throughput

0.536

High

617384

PGM2
Phosphoglucomutase 2

1

0

High-throughput

0.513

High

617387

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.513

High

359425

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

6

High-throughput

0.500

High

367685

ENO1
Enolase 1

1

4

High-throughput

0.500

High

392193

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.500

High

394213

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.500

High

408284

GAL1
Galactokinase

1

3

High-throughput

0.500

High

481471

HSP73
Heat shock protein SSA3

1

16

High-throughput

0.500

High

531235

METK1
S-adenosylmethionine synthase 1

1

3

High-throughput

0.500

High

543752

SSB1
Ribosome-associated molecular chaperone SSB1

1

17

High-throughput

0.500

High

555001

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.500

High

578803

HSC82
ATP-dependent molecular chaperone HSC82

1

10

High-throughput

0.500

High

590522

HSP26
Heat shock protein 26

1

1

High-throughput

0.500

High

617372

SCJ1
DnaJ-related protein SCJ1

1

12

High-throughput

0.500

High

617385

GLYC
Serine hydroxymethyltransferase, cytosolic

1

1

High-throughput

0.500

High

617389

YHI0
Putative proline--tRNA ligase YHR020W

1

4

High-throughput

0.500

High

617390

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.500

High

617397

SAHH
Adenosylhomocysteinase

1

2

High-throughput

0.500

High

617406

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.500

High

455476

PMM
Phosphomannomutase

1

1

High-throughput

0.489

High

617378

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

11

High-throughput

0.489

High

617402

SYG1
Protein SYG1

1

0

Small-scale

0.486

High

617370

KIN3
Serine/threonine-protein kinase KIN3

1

7

High-throughput

0.481

High

617411

AF9
Protein AF-9 homolog

1

6

High-throughput

0.481

High

432285

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

439233

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

550745

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.479

High

448508

RHO1
GTP-binding protein RHO1

1

14

Small-scale

0.479

High

617412

APJ1
J domain-containing protein APJ1

1

15

High-throughput

0.479

High

617379

SSO1
Protein SSO1

1

0

High-throughput

0.460

High

617399

DSE1
Protein DSE1

1

0

Small-scale

0.458

High

617409

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

599317

FUS3
Mitogen-activated protein kinase FUS3

1

9

Small-scale

0.457

High

367356

CISY1
Citrate synthase, mitochondrial

1

1

High-throughput

0.457

High

405019

LEU3
3-isopropylmalate dehydrogenase

1

4

High-throughput

0.457

High

408550

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

2

High-throughput

0.457

High

575377

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

4

High-throughput

0.457

High

617405

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

3

High-throughput

0.457

High

617414

PRS8
26S proteasome regulatory subunit 8 homolog

1

10

High-throughput

0.457

High

453410

PYR1
Multifunctional protein URA2

1

7

High-throughput

0.445

High

510170

HSP77
Import motor subunit, mitochondrial

1

19

High-throughput

0.445

High

522994

HSP71
Heat shock protein SSA1

1

16

High-throughput

0.445

High

525870

HSP72
Heat shock protein SSA2

1

16

High-throughput

0.445

High

617382

PRS7
26S proteasome regulatory subunit 7 homolog

1

13

High-throughput

0.445

High

617383

NUF2
Kinetochore protein NUF2

1

7

High-throughput

0.439

High

617376

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

617380

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

617398

RPN3
26S proteasome regulatory subunit RPN3

1

2

High-throughput

0.407

High

617374

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.279

Low

617386

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.251

Low

617403

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025