Interactor 1: PDE1B (Q01064)
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
Gene: PDE1B

Interactor 2: PDE1C (Q14123)
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3)
Gene: PDE1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PDEase_I~PDEase_I
Common GO terms GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117 - calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005516 - calmodulin binding
GO:0005829 - cytosol
GO:0019933 - cAMP-mediated signaling
and 4 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 536
Hs

1 709
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Last updated: 15 Jul 2024