Protein: S61A1
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)

Gene: S61A1, SEC61A1
Organism: Homo sapiens
Interactions: 216
UniProt ID: P61619

Gene Ontology (top 5):
GO:0005048 - signal sequence binding
GO:0005262 - calcium channel activity
GO:0005784 - Sec61 translocon complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006613 - cotranslational protein targeting to membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

951055

SC61B
Protein transport protein Sec61 subunit beta

7

6

Small-scale

0.956

High

563531

CFTR
Cystic fibrosis transmembrane conductance regulator

4

3

High-throughput

0.691

High

363078

EGFR
Epidermal growth factor receptor

4

4

Small-scale

0.686

High

698552

CALX
Calnexin

4

1

Small-scale

0.683

High

963148

SEC63
Translocation protein SEC63 homolog

1

6

High-throughput

0.665

High

842292

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.656

High

948996

SC61G
Protein transport protein Sec61 subunit gamma

1

2

Small-scale

0.647

High

963136

S61A2
Protein transport protein Sec61 subunit alpha isoform 2

1

2

High-throughput

0.618

High

534869

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.611

High

963057

ILK
Scaffold protein ILK

2

0

High-throughput

0.602

High

241279

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

410750

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

4

High-throughput

0.584

High

963104

RN149
E3 ubiquitin-protein ligase RNF149

2

2

Small-scale

0.584

High

584506

VAV
Proto-oncogene vav

3

1

High-throughput

0.578

High

400588

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

1

High-throughput

0.569

High

345603

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

963125

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

939916

TPTE
Putative tyrosine-protein phosphatase TPTE

1

3

High-throughput

0.554

High

847493

SSRA
Translocon-associated protein subunit alpha

1

0

Small-scale

0.546

High

411683

NTRK1
High affinity nerve growth factor receptor

2

8

High-throughput

0.543

High

303483

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.536

High

322919

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

2

High-throughput

0.536

High

465467

IGF1R
Insulin-like growth factor 1 receptor

1

8

High-throughput

0.536

High

963043

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.536

High

963090

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.536

High

963096

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.536

High

963102

S15A4
Solute carrier family 15 member 4

1

1

Small-scale

0.536

High

963114

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

963134

SG196
Protein O-mannose kinase

1

1

High-throughput

0.536

High

611070

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

2

High-throughput

0.533

High

963067

TNIP1
TNFAIP3-interacting protein 1

2

3

High-throughput

0.533

High

963092

VTCN1
V-set domain-containing T-cell activation inhibitor 1

1

0

Small-scale

0.517

High

446835

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

459529

PROF1
Profilin-1

1

0

High-throughput

0.513

High

479369

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

785047

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

859181

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

866972

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

884023

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

945204

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.513

High

963041

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

963046

RACK1
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.513

High

963048

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

963062

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

963131

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.513

High

963140

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

223993

GET3
ATPase GET3

1

1

Small-scale

0.501

High

439694

INSR
Insulin receptor

1

8

High-throughput

0.500

High

484096

PGFRB
Platelet-derived growth factor receptor beta

1

7

High-throughput

0.500

High

963054

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

7

High-throughput

0.500

High

390521

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

963040

AP1S1
AP-1 complex subunit sigma-1A

1

0

High-throughput

0.493

High

762118

CNR2
Cannabinoid receptor 2

1

1

Small-scale

0.489

High

777661

VGFR3
Vascular endothelial growth factor receptor 3

1

4

High-throughput

0.489

High

907357

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.489

High

963070

NTRK3
NT-3 growth factor receptor

1

8

High-throughput

0.489

High

963073

DDR2
Discoidin domain-containing receptor 2

1

7

High-throughput

0.489

High

963084

STYK1
Tyrosine-protein kinase STYK1

1

1

High-throughput

0.489

High

963109

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

1

High-throughput

0.489

High

963112

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

6

High-throughput

0.489

High

963123

RBM42
RNA-binding protein 42

1

1

High-throughput

0.489

High

963150

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.489

High

827365

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.486

High

856626

BAG6
Large proline-rich protein BAG6

1

0

Small-scale

0.480

High

299136

FLOT1
Flotillin-1

1

1

High-throughput

0.479

High

375350

RASK
GTPase KRas

1

1

High-throughput

0.479

High

403153

APOB
Apolipoprotein B-100

1

2

Small-scale

0.479

High

472031

MET
Hepatocyte growth factor receptor

1

6

High-throughput

0.479

High

477225

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

7

High-throughput

0.479

High

507765

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.479

High

598052

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

High-throughput

0.479

High

622566

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.479

High

630237

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.479

High

876800

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.479

High

903864

BAP31
B-cell receptor-associated protein 31

1

3

Small-scale

0.479

High

925508

MOT1
Monocarboxylate transporter 1

1

4

High-throughput

0.479

High

932563

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

3

High-throughput

0.479

High

963044

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

963051

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

963052

LAT1
Large neutral amino acids transporter small subunit 1

1

1

High-throughput

0.479

High

963056

CLN3
Battenin

1

1

Small-scale

0.479

High

963060

CUL3
Cullin-3

1

1

High-throughput

0.479

High

963079

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

3

High-throughput

0.479

High

963094

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

Small-scale

0.479

High

963097

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

963107

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

963120

DERL3
Derlin-3

1

3

Small-scale

0.479

High

963122

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

963124

DERL1
Derlin-1

1

3

Small-scale

0.479

High

963129

DERL2
Derlin-2

1

3

Small-scale

0.479

High

963138

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

963142

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

963153

SRPRB
Signal recognition particle receptor subunit beta

1

3

High-throughput

0.479

High

284389

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

Small-scale

0.458

High

409336

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

Small-scale

0.458

High

458361

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

488762

FURIN
Furin

1

0

High-throughput

0.458

High

536884

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

692910

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

774265

BASI
Basigin

1

0

High-throughput

0.458

High

799828

COIL
Coilin

1

0

High-throughput

0.458

High

960054

RL26
Large ribosomal subunit protein uL24

1

0

Small-scale

0.458

High

963080

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.458

High

963085

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

963086

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

963088

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

963091

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

963105

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

963116

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

963146

NCDN
Neurochondrin

1

0

High-throughput

0.458

High

963149

TMCO1
Calcium load-activated calcium channel

1

0

Small-scale

0.458

High

951572

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.457

High

963053

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

8

High-throughput

0.457

High

97242

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.445

High

282574

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

3

Small-scale

0.445

High

870350

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

1

High-throughput

0.445

High

923411

SC5A3
Sodium/myo-inositol cotransporter

1

3

High-throughput

0.445

High

963095

S22AG
Solute carrier family 22 member 16

1

2

High-throughput

0.445

High

164306

NRP1
Neuropilin-1

1

1

High-throughput

0.437

High

188854

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.437

High

277340

TP4A3
Protein tyrosine phosphatase type IVA 3

1

3

High-throughput

0.437

High

293477

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

580611

AMPN
Aminopeptidase N

1

1

High-throughput

0.437

High

582566

PPAP
Prostatic acid phosphatase

1

1

High-throughput

0.437

High

609978

VGFR1
Vascular endothelial growth factor receptor 1

1

4

High-throughput

0.437

High

626147

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.437

High

650112

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.437

High

717429

PDIA3
Protein disulfide-isomerase A3

1

1

Small-scale

0.437

High

720174

UFO
Tyrosine-protein kinase receptor UFO

1

6

High-throughput

0.437

High

786998

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

4

High-throughput

0.437

High

832362

OPRD
Delta-type opioid receptor

1

1

Small-scale

0.437

High

919856

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.437

High

963050

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

1

High-throughput

0.437

High

963066

CUL7
Cullin-7

1

1

High-throughput

0.437

High

963068

T22D1
TSC22 domain family protein 1

1

1

High-throughput

0.437

High

963069

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

963074

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

4

High-throughput

0.437

High

963075

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

963077

KCD21
BTB/POZ domain-containing protein KCTD21

1

1

Small-scale

0.437

High

963087

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

963093

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

963100

TM192
Transmembrane protein 192

1

1

High-throughput

0.437

High

963118

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.437

High

963133

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

963144

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.437

High

963145

WWOX
WW domain-containing oxidoreductase

1

3

High-throughput

0.437

High

963151

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.437

High

963152

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.437

High

963154

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.437

High

425416

ISG15
Ubiquitin-like protein ISG15

1

3

Small-scale

0.407

High

963076

SC5A9
Sodium/glucose cotransporter 4

1

3

High-throughput

0.407

High

963082

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

963115

Q96D37
VAV1 protein

1

1

High-throughput

0.407

High

218026

TGON2
Trans-Golgi network integral membrane protein 2

3

0

High-throughput

0.330

High

963147

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.305

High

371637

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.298

High

963045

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.279

Low

963063

RBM39
RNA-binding protein 39

1

0

High-throughput

0.279

Low

963111

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.279

Low

963127

REN3B
Regulator of nonsense transcripts 3B

1

0

High-throughput

0.279

Low

963137

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

1

0

High-throughput

0.279

Low

155099

SOCS2
Suppressor of cytokine signaling 2

1

0

High-throughput

0.269

Low

680687

CATS
Cathepsin S

1

0

High-throughput

0.269

Low

830471

CCNF
Cyclin-F

1

0

High-throughput

0.269

Low

963121

NECD
Necdin

1

0

High-throughput

0.269

Low

378029

TNFA
Tumor necrosis factor

1

0

Small-scale

0.261

Low

963128

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

128915

MEN1
Menin

1

0

High-throughput

0.249

Low

343243

ERR2
Steroid hormone receptor ERR2

1

0

High-throughput

0.249

Low

413527

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

588376

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

615701

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.249

Low

695107

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

767864

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

861102

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.249

Low

878878

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

886395

CTCF
Transcriptional repressor CTCF

1

0

Small-scale

0.249

Low

897196

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.249

Low

904532

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

916222

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.249

Low

926915

ATX3
Ataxin-3

1

0

High-throughput

0.249

Low

963042

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

963047

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

963049

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.249

Low

963055

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

963058

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

963059

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

Small-scale

0.249

Low

963061

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

963064

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.249

Low

963071

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

963072

DUS7
Dual specificity protein phosphatase 7

1

0

High-throughput

0.249

Low

963078

MIDN
Midnolin

1

0

High-throughput

0.249

Low

963081

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

963083

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

963089

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

963098

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.249

Low

963099

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

963103

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.249

Low

963106

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

963108

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

963110

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.249

Low

963113

FBX32
F-box only protein 32

1

0

High-throughput

0.249

Low

963117

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

963119

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

963126

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.249

Low

963130

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

963135

WDR76
WD repeat-containing protein 76

1

0

High-throughput

0.249

Low

963139

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

963141

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

963143

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

998

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

143420

E2F3
Transcription factor E2F3

1

0

Small-scale

0.232

Low

244944

KATIP
Katanin-interacting protein

1

0

High-throughput

0.232

Low

963065

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.232

Low

963101

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

963132

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025