HitPredict

Interactor 1: SRSF2 (Q01130)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	8816452, 37071682
Identification Methods	two hybrid, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Hs			1 248
+	Hs
		1028926 SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		516493 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25
+	Hs
		963976 SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		963970 SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		516478 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		992743 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		516339 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		951977 SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		516689 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		PABP3_HUMAN (8-203): 1.09e-33: 129: 16.18
+	Hs
		516484 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		516466 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		951927 SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		963995 SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		951937 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		474019 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		PAB4L_HUMAN (17-92): 5.07e-19: 86.6: 19.48
+	Zm
		30171 A0A1D6K4S7_MAIZE (3-93): 2.97e-41: 146: 47.83		A0A1D6M1U3_MAIZE (116-219): 4.4e-15: 75.4: 18.52
+	Hs
		516495 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67
+	Hs
		516471 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		TIAR_HUMAN (113-202): 2.85e-10: 61.5: 12.63
+	Mm
		665745 PABP1_MOUSE (6-202): 2.07e-41: 150: 18.27		TIA1_MOUSE (115-203): 5.51e-10: 60.8: 11.70
+	Mm
		857332 SRSF2_MOUSE (1-221): 1.22e-43: 147: 100.00		TIA1_MOUSE (115-203): 5.51e-10: 60.8: 11.70