Protein: NPC2
NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) (Human epididymis-specific protein 1) (He1) (Niemann-Pick disease type C2 protein)

Gene: NPC2
Organism: Homo sapiens
Interactions: 60
UniProt ID: P61916

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005764 - lysosome
GO:0005783 - endoplasmic reticulum
GO:0008203 - cholesterol metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

543413

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

0

High-throughput

0.656

High

963958

RRAGA
Ras-related GTP-binding protein A

3

0

High-throughput

0.638

High

366575

CFAB
Complement factor B

2

1

High-throughput

0.628

High

178236

NPC1
NPC intracellular cholesterol transporter 1

1

0

Small-scale

0.614

High

648128

NDKB
Nucleoside diphosphate kinase B

2

3

High-throughput

0.611

High

389809

TTHY
Transthyretin

2

0

High-throughput

0.602

High

914146

HXK3
Hexokinase-3

2

0

High-throughput

0.602

High

947974

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

963965

IRGQ
Immunity-related GTPase family Q protein

2

0

High-throughput

0.602

High

963961

TM11B
Transmembrane protease serine 11B

2

0

High-throughput

0.585

High

248204

NDK8
Putative nucleoside diphosphate kinase

2

3

High-throughput

0.552

High

963960

DHDDS
Dehydrodolichyl diphosphate synthase complex subunit DHDDS

1

0

Small-scale

0.549

High

548465

MPRI
Cation-independent mannose-6-phosphate receptor

1

1

High-throughput

0.536

High

963971

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

Small-scale

0.529

High

963959

NEGR1
Neuronal growth regulator 1

1

0

Small-scale

0.519

High

351820

BY55
CD160 antigen

1

0

High-throughput

0.513

High

465840

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.513

High

566899

CO6
Complement component C6

1

0

High-throughput

0.513

High

655988

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

963966

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

0

High-throughput

0.513

High

963970

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.513

High

963977

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.513

High

963978

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

0

High-throughput

0.513

High

463045

YES
Tyrosine-protein kinase Yes

1

0

High-throughput

0.493

High

180765

TIF1A
Transcription intermediary factor 1-alpha

1

1

High-throughput

0.489

High

798925

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.481

High

963951

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

Small-scale

0.460

High

963979

ERRFI
ERBB receptor feedback inhibitor 1

1

0

Small-scale

0.460

High

580612

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

963963

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

963969

ESPB1
Epididymal sperm-binding protein 1

1

1

High-throughput

0.445

High

963957

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.439

High

963956

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

327040

NXPH3
Neurexophilin-3

1

0

High-throughput

0.426

High

369173

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

380275

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.426

High

956040

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.426

High

963955

ADIPO
Adiponectin

1

0

High-throughput

0.426

High

963962

TMM25
Transmembrane protein 25

1

0

High-throughput

0.426

High

963976

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

104719

F6XY72
nucleoside-diphosphate kinase

1

3

High-throughput

0.407

High

270705

LDB3
LIM domain-binding protein 3

3

0

High-throughput

0.347

High

841536

I12R1
Interleukin-12 receptor subunit beta-1

2

0

High-throughput

0.313

High

963972

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.288

High

876306

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

898213

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

High-throughput

0.279

Low

963950

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

0

High-throughput

0.279

Low

963954

EPHA7
Ephrin type-A receptor 7

1

0

High-throughput

0.279

Low

963967

TSR2
Pre-rRNA-processing protein TSR2 homolog

1

0

High-throughput

0.279

Low

892657

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

963953

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.251

Low

963975

ECT2
Protein ECT2

1

0

High-throughput

0.251

Low

123072

DX39A
ATP-dependent RNA helicase DDX39A

1

0

High-throughput

0.249

Low

218029

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

942528

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

963952

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

963964

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.232

Low

963968

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low

963973

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

0

High-throughput

0.232

Low

963974

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025