HitPredict

Interactor 1: RUNX1 (Q01196)
Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)
Gene: RUNX1

Interactor 2: SMRC2 (Q8TAQ2)
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)
Gene: SMARCC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28533407
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 453 Hs			1 1214
+	Hs
		964384 RUNX1_HUMAN (1-453): 0: 702: 100.00		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Mm
		1112970 Q3UM65_MOUSE (6-453): 0: 679: 95.76		SMRC2_MOUSE (1-1203): 0: 957: 96.51
+	Mm
		956810 Q3UM65_MOUSE (6-453): 0: 679: 95.76		SMRC1_MOUSE (4-1028): 0: 952: 64.13
+	Hs
		159962 RUNX1_HUMAN (1-453): 0: 702: 100.00		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Hs
		964472 RUNX1_HUMAN (1-453): 0: 702: 100.00		NCOR2_HUMAN (588-1208): 2.06e-32: 139: 14.22
+	Hs
		261472 RUNX1_HUMAN (1-453): 0: 702: 100.00		NCOR1_HUMAN (597-1154): 8.84e-32: 137: 10.86
+	Mm
		70920 Q3UM65_MOUSE (6-453): 0: 679: 95.76		EP300_MOUSE (885-1214): 8.74e-09: 62.4: 13.78
+	Mm
		70917 RUNX2_MOUSE (43-453): 0: 539: 64.11		EP300_MOUSE (885-1214): 8.74e-09: 62.4: 13.78