Protein: TRIM5
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)

Gene: TRIM5
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q9C035

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0002218 - activation of innate immune response
GO:0003713 - transcription coactivator activity
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1420571

TRIM5
Tripartite motif-containing protein 5

15

16

Small-scale

0.985

High

957664

UBE2K
Ubiquitin-conjugating enzyme E2 K

4

20

High-throughput

0.892

High

957837

UBE2N
Ubiquitin-conjugating enzyme E2 N

3

20

Small-scale

0.878

High

1418709

TRI34
E3 ubiquitin-protein ligase TRIM34

3

16

Small-scale

0.865

High

982313

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.858

High

957192

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

Small-scale

0.857

High

1420569

TRIM6
Tripartite motif-containing protein 6

2

16

Small-scale

0.767

High

1420576

UBQL2
Ubiquilin-2

2

11

High-throughput

0.754

High

1093416

TRI32
E3 ubiquitin-protein ligase TRIM32

1

18

High-throughput

0.733

High

906776

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

High-throughput

0.698

High

971046

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

1093711

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

2

High-throughput

0.698

High

1103936

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

1154294

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

High-throughput

0.698

High

1420579

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

73742

B2RNG4
RING-type E3 ubiquitin transferase

1

16

High-throughput

0.691

High

508576

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

11

Small-scale

0.647

High

623524

RO52
E3 ubiquitin-protein ligase TRIM21

1

16

Small-scale

0.647

High

1383932

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

Small-scale

0.647

High

1420578

TRI35
E3 ubiquitin-protein ligase TRIM35

1

15

Small-scale

0.647

High

564340

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.633

High

1218760

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

507358

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

11

Small-scale

0.621

High

1255429

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1409935

DDX50
ATP-dependent RNA helicase DDX50

1

7

High-throughput

0.618

High

226875

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

6

High-throughput

0.606

High

463214

YES
Tyrosine-protein kinase Yes

2

8

High-throughput

0.606

High

943814

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

9

High-throughput

0.606

High

1325117

MTURN
Maturin

2

2

High-throughput

0.606

High

1392896

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

2

High-throughput

0.606

High

929831

SYYC
Tyrosine--tRNA ligase, cytoplasmic

2

0

High-throughput

0.602

High

503654

TFPT
TCF3 fusion partner

2

2

High-throughput

0.601

High

1420572

CUED1
CUE domain-containing protein 1

2

1

High-throughput

0.574

High

778774

PRS7
26S proteasome regulatory subunit 7

1

7

Small-scale

0.573

High

609799

LEG3
Galectin-3

1

14

Small-scale

0.561

High

1187681

T10IP
Testis-specific protein 10-interacting protein

2

2

High-throughput

0.553

High

1212206

MPP7
MAGUK p55 subfamily member 7

2

3

High-throughput

0.553

High

908782

MAT1
CDK-activating kinase assembly factor MAT1

1

7

High-throughput

0.541

High

1033208

EWS
RNA-binding protein EWS

1

8

High-throughput

0.541

High

1154168

ITSN1
Intersectin-1

1

3

High-throughput

0.541

High

593205

CREB1
Cyclic AMP-responsive element-binding protein 1

1

3

High-throughput

0.536

High

1278848

DCXR
L-xylulose reductase

1

3

High-throughput

0.536

High

1384121

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.536

High

75532

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

961635

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.518

High

329972

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

3

High-throughput

0.515

High

1064023

ECHP
Peroxisomal bifunctional enzyme

1

4

High-throughput

0.515

High

1420580

SHLB1
Endophilin-B1

1

4

High-throughput

0.515

High

127394

LEG8
Galectin-8

1

14

Small-scale

0.501

High

297685

PIAS1
E3 SUMO-protein ligase PIAS1

1

7

Small-scale

0.501

High

424676

KPCG
Protein kinase C gamma type

1

10

Small-scale

0.501

High

991418

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.501

High

1328759

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

4

High-throughput

0.494

High

1316924

FAM9C
Protein FAM9C

1

2

High-throughput

0.489

High

288510

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

17

High-throughput

0.481

High

639306

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

High-throughput

0.481

High

853523

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

20

High-throughput

0.481

High

1199458

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

20

High-throughput

0.481

High

1387334

OTUB2
Ubiquitin thioesterase OTUB2

1

4

High-throughput

0.481

High

1420573

TBA8
Tubulin alpha-8 chain

1

12

High-throughput

0.481

High

1420577

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

14

High-throughput

0.481

High

1420581

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

17

High-throughput

0.481

High

1029933

RUNX1
Runt-related transcription factor 1

1

0

Small-scale

0.480

High

173323

XPO1
Exportin-1

1

3

High-throughput

0.479

High

193304

SOCS1
Suppressor of cytokine signaling 1

1

11

Small-scale

0.479

High

214026

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

9

Small-scale

0.479

High

271573

ATG13
Autophagy-related protein 13

1

2

Small-scale

0.479

High

331299

KI20A
Kinesin-like protein KIF20A

1

19

High-throughput

0.479

High

350132

SNAI1
Zinc finger protein SNAI1

1

20

Small-scale

0.479

High

841930

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

Small-scale

0.479

High

851413

PRS6B
26S proteasome regulatory subunit 6B

1

7

Small-scale

0.479

High

906597

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

3

Small-scale

0.479

High

969048

PRS8
26S proteasome regulatory subunit 8

1

9

Small-scale

0.479

High

1098841

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

8

Small-scale

0.479

High

1108121

SQSTM
Sequestosome-1

1

7

Small-scale

0.479

High

1114229

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1117259

NCOA4
Nuclear receptor coactivator 4

1

1

Small-scale

0.479

High

1140810

KIF14
Kinesin-like protein KIF14

1

16

High-throughput

0.479

High

1159140

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

2

Small-scale

0.479

High

1327554

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

10

Small-scale

0.479

High

1351968

RBCC1
RB1-inducible coiled-coil protein 1

1

20

Small-scale

0.479

High

1406018

PHB2
Prohibitin-2

1

6

Small-scale

0.479

High

1420574

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

11

Small-scale

0.479

High

1420575

DAXX
Death domain-associated protein 6

1

3

Small-scale

0.479

High

1420582

NEMO
NF-kappa-B essential modulator

1

16

Small-scale

0.479

High

562380

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.470

High

270737

N4BP1
NEDD4-binding protein 1

1

0

Small-scale

0.458

High

276172

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.458

High

1349476

F110B
Protein FAM110B

1

2

High-throughput

0.445

High

1273064

OTU6A
OTU domain-containing protein 6A

1

3

High-throughput

0.439

High

947045

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025