HitPredict

Interactor 1: CAP1 (Q01518)
Adenylyl cyclase-associated protein 1 (CAP 1)
Gene: CAP1

Interactor 2: TWF1 (Q12792)
Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)
Gene: TWF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0005925 - focal adhesion
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 475 Hs			1 350
+	Hs
		965198 CAP1_HUMAN (1-475): 0: 711: 100.00		TWF2_HUMAN (1-344): 3.79e-159: 451: 65.41
+	Hs
		768472 CAP2_HUMAN (1-473): 0: 647: 63.05		TWF1_HUMAN (1-350): 5.66e-171: 481: 100.00
+	Hs
		768480 CAP2_HUMAN (1-473): 0: 647: 63.05		TWF2_HUMAN (1-344): 3.79e-159: 451: 65.41
+	Hs
		618057 CAP1_HUMAN (1-475): 0: 711: 100.00		COF1_HUMAN (4-142): 6.84e-37: 132: 17.09
+	Hs
		768477 CAP2_HUMAN (1-473): 0: 647: 63.05		Q549N0_HUMAN (4-138): 2.83e-38: 136: 17.53
+	Hs
		768490 CAP2_HUMAN (1-473): 0: 647: 63.05		COF2_HUMAN (4-138): 2.83e-38: 136: 17.53
+	Hs
		618009 CAP2_HUMAN (1-473): 0: 647: 63.05		COF1_HUMAN (4-142): 6.84e-37: 132: 17.09
+	Sc
		568333 CAP_YEAST (3-475): 5.74e-178: 510: 32.56		TWF1_YEAST (1-334): 4.1e-86: 264: 24.65
+	Sc
		568342 CAP_YEAST (3-475): 5.74e-178: 510: 32.56		COFI_YEAST (1-142): 2.08e-42: 146: 22.60
+	Sp
		737042 CAP_SCHPO (14-473): 8.25e-175: 503: 32.92		COFI_SCHPO (5-141): 7.25e-42: 144: 24.46