HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	16189514
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 656 Hs			1 551
+	Hs
		1084556 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Mm
		1156791 Q8BQ46_MOUSE (109-555): 4.7e-53: 193: 35.35		CPSF6_MOUSE (1-520): 4.58e-92: 294: 99.62
+	Hs
		318629 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		726853 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		847043 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		967279 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		846937 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		1031411 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		726671 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		516620 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		726795 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		967541 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		PCLO_HUMAN (131-447): 2.08e-14: 78.8: 12.23
+	Hs
		967221 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18
+	Hs
		867093 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SC24C_HUMAN (233-440): 1.79e-12: 72.2: 17.05
+	Hs
		297856 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SC24D_HUMAN (131-353): 2.02e-11: 68.8: 21.49
+	Hs
		516383 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Mm
		956882 EYA1_MOUSE (3-277): 2.57e-40: 157: 22.50		SMCA4_MOUSE (172-423): 2.26e-10: 65.7: 12.30
+	Hs
		318721 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Hs
		318751 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		ZMIZ1_HUMAN (159-374): 8.13e-09: 60.7: 17.72
+	Sc
		376785 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96