HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: ANM8 (Q9NR22)
Protein arginine N-methyltransferase 8 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4)
Gene: PRMT8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	26186194, 28514442, 18320585, 33961781
Identification Methods	affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 394
+	Hs
		1271197 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		ANM8_HUMAN (1-394): 0: 551: 100.00
+	Hs
		1271175 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		ANM1_HUMAN (51-394): 1.24e-173: 490: 80.23
+	Hs
		727051 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		ANM8_HUMAN (1-394): 0: 551: 100.00
+	Hs
		967391 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ANM1_HUMAN (51-394): 1.24e-173: 490: 80.23
+	Hs
		318710 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		ANM1_HUMAN (51-394): 1.24e-173: 490: 80.23
+	Hs
		727010 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		ANM1_HUMAN (51-394): 1.24e-173: 490: 80.23
+	Mm
		882703 FUS_MOUSE (66-545): 4.19e-27: 117: 32.08		ANM1_MOUSE (51-394): 1.61e-173: 490: 80.23
+	Sc
		743530 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		HMT1_YEAST (60-393): 3.26e-141: 407: 46.63
+	Hs
		153646 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ANM5_HUMAN (66-365): 8.63e-70: 232: 16.72
+	Hs
		153589 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		ANM5_HUMAN (66-365): 8.63e-70: 232: 16.72