HitPredict

Interactor 1: PDCD1 (Q02242)
Programmed cell death protein 1 (Protein PD-1) (mPD-1) (CD antigen CD279)
Gene: PDCD1

Interactor 2: PD1L1 (Q9EP73)
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Gene: Cd274

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	18641123, 12719480, 17606978, 23417675, 21884581
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C2-set_2~V-set, V-set~V-set
Common GO terms	GO:0002250 - adaptive immune response GO:0009897 - external side of plasma membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 288 Mm			1 290
+	Mm
		970114 PDCD1_MOUSE (1-288): 0: 517: 100.00		PD1L2_MOUSE (19-263): 1.36e-51: 171: 33.47
+	Hs
		1067951 PDCD1_HUMAN (1-288): 2e-154: 434: 56.90		PD1L1_HUMAN (1-290): 5.26e-62: 199: 67.70
+	Hs
		706897 PDCD1_HUMAN (1-288): 2e-154: 434: 56.90		CD80_HUMAN (1-258): 6.89e-41: 144: 18.35
+	Hs
		1067939 PDCD1_HUMAN (1-288): 2e-154: 434: 56.90		PD1L2_HUMAN (19-288): 2.37e-38: 138: 35.17