Protein: TBC15
TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP)

Gene: TBC15, TBC1D15
Organism: Homo sapiens
Interactions: 196
UniProt ID: Q8TC07

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0043087 - regulation of GTPase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1349335

TBC17
TBC1 domain family member 17

3

8

High-throughput

0.855

High

1349310

OPTN
Optineurin

6

5

High-throughput

0.737

High

212456

SPIT2
Kunitz-type protease inhibitor 2

4

7

High-throughput

0.691

High

1290910

TAXB1
Tax1-binding protein 1

4

6

Small-scale

0.684

High

906121

AL3A2
Aldehyde dehydrogenase family 3 member A2

3

1

High-throughput

0.667

High

896830

DYN2
Dynamin-2

3

3

High-throughput

0.662

High

1132622

KIF22
Kinesin-like protein KIF22

3

2

High-throughput

0.662

High

1349298

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

3

1

High-throughput

0.662

High

1349314

CEP63
Centrosomal protein of 63 kDa

5

3

High-throughput

0.658

High

508317

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

3

High-throughput

0.651

High

1333675

UBAC2
Ubiquitin-associated domain-containing protein 2

4

1

High-throughput

0.636

High

878685

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

3

0

High-throughput

0.634

High

1349346

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

0

High-throughput

0.634

High

122632

UBXN8
UBX domain-containing protein 8

4

2

High-throughput

0.630

High

1294797

STX12
Syntaxin-12

4

6

High-throughput

0.630

High

622641

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

1

High-throughput

0.628

High

1050701

DYN1
Dynamin-1

2

3

High-throughput

0.628

High

631363

RAB5A
Ras-related protein Rab-5A

1

20

Small-scale

0.621

High

719245

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.618

High

1349354

FIS1
Mitochondrial fission 1 protein

3

2

Small-scale

0.615

High

908711

CCNH
Cyclin-H

3

2

High-throughput

0.609

High

1124868

FLOT2
Flotillin-2

3

2

High-throughput

0.609

High

1256686

CC121
Coiled-coil domain-containing protein 121

3

1

High-throughput

0.609

High

1245970

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

3

1

High-throughput

0.604

High

1349318

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

3

4

High-throughput

0.604

High

1349334

PACC1
Proton-activated chloride channel

3

2

High-throughput

0.604

High

74048

MYO9A
Unconventional myosin-IXa

2

1

High-throughput

0.601

High

1084053

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

2

0

High-throughput

0.585

High

242360

PRKN
E3 ubiquitin-protein ligase parkin

2

7

Small-scale

0.584

High

1349299

THEM6
Protein THEM6

2

0

High-throughput

0.576

High

1349337

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

1

High-throughput

0.574

High

193601

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

3

High-throughput

0.571

High

1349323

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

20

High-throughput

0.555

High

900942

RAB5C
Ras-related protein Rab-5C

1

20

Small-scale

0.555

High

956596

RAB5B
Ras-related protein Rab-5B

1

20

Small-scale

0.555

High

901415

RAB7A
Ras-related protein Rab-7a

1

20

High-throughput

0.553

High

945050

RAB25
Ras-related protein Rab-25

1

19

High-throughput

0.553

High

733024

VIPR1
Vasoactive intestinal polypeptide receptor 1

2

8

High-throughput

0.549

High

1101600

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

12

High-throughput

0.549

High

1349329

UN93B
Protein unc-93 homolog B1

2

2

High-throughput

0.549

High

351931

S1PR4
Sphingosine 1-phosphate receptor 4

1

9

High-throughput

0.536

High

564103

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

638219

S1PR1
Sphingosine 1-phosphate receptor 1

1

9

High-throughput

0.536

High

969990

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

1154876

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.536

High

1310255

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1349307

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1349331

CLC4M
C-type lectin domain family 4 member M

1

4

High-throughput

0.536

High

1349336

LPAR2
Lysophosphatidic acid receptor 2

1

9

High-throughput

0.536

High

1349351

DYN3
Dynamin-3

1

3

High-throughput

0.536

High

1349353

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

1

High-throughput

0.536

High

328077

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.535

High

952254

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.527

High

1349344

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

5

High-throughput

0.523

High

955976

RAB8A
Ras-related protein Rab-8A

1

19

Small-scale

0.514

High

376626

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.513

High

1207241

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

1334384

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.513

High

1349319

ABHEA
Protein ABHD14A

1

0

High-throughput

0.513

High

1349322

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

0

High-throughput

0.513

High

1349352

PSG8
Pregnancy-specific beta-1-glycoprotein 8

1

0

High-throughput

0.513

High

179987

BET1
BET1 homolog

1

3

High-throughput

0.489

High

210412

MTLR
Motilin receptor

1

3

High-throughput

0.489

High

486592

TACD2
Tumor-associated calcium signal transducer 2

1

5

High-throughput

0.489

High

640427

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

6

High-throughput

0.489

High

835334

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

7

High-throughput

0.489

High

867993

GLR
Glucagon receptor

1

12

High-throughput

0.489

High

936091

PAR2
Proteinase-activated receptor 2

1

9

High-throughput

0.489

High

1112928

CUL2
Cullin-2

1

5

High-throughput

0.489

High

1142107

P2RY6
P2Y purinoceptor 6

1

12

High-throughput

0.489

High

1249819

BTNL9
Butyrophilin-like protein 9

1

7

High-throughput

0.489

High

1258841

CYS1
Cystin-1

1

1

High-throughput

0.489

High

1291636

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

3

High-throughput

0.489

High

1331635

LRTM2
Leucine-rich repeat and transmembrane domain-containing protein 2

1

4

High-throughput

0.489

High

1349355

GPR45
Probable G-protein coupled receptor 45

1

5

High-throughput

0.489

High

1349327

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.481

High

125534

LEG9
Galectin-9

1

2

High-throughput

0.479

High

173113

XPO1
Exportin-1

1

8

High-throughput

0.479

High

277382

TP4A3
Protein tyrosine phosphatase type IVA 3

1

2

High-throughput

0.479

High

294067

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

445983

ENOA
Alpha-enolase

1

3

High-throughput

0.479

High

606931

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

611243

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

831103

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

862317

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

1004871

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

1010078

DLK1
Protein delta homolog 1

1

2

High-throughput

0.479

High

1107950

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

1109919

HDAC1
Histone deacetylase 1

1

3

High-throughput

0.479

High

1113778

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1140594

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1251090

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

1

High-throughput

0.479

High

1254755

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1294214

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

1295503

MIB1
E3 ubiquitin-protein ligase MIB1

1

1

High-throughput

0.479

High

1349300

DNJC9
DnaJ homolog subfamily C member 9

1

3

High-throughput

0.479

High

1349324

WWTR1
WW domain-containing transcription regulator protein 1

1

6

High-throughput

0.479

High

1349326

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

1349328

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1349332

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1349333

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1349342

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

642981

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.470

High

346096

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

705715

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

0

High-throughput

0.458

High

1026472

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1156789

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1333294

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1334678

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1349304

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1349313

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1349321

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

20

High-throughput

0.457

High

166357

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.445

High

325943

UBR5
E3 ubiquitin-protein ligase UBR5

1

4

High-throughput

0.445

High

912794

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

1

3

High-throughput

0.445

High

934891

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.445

High

1315817

AN13A
Ankyrin repeat domain-containing protein 13A

1

1

High-throughput

0.445

High

1349302

LPAR1
Lysophosphatidic acid receptor 1

1

9

High-throughput

0.445

High

1349315

S1PR3
Sphingosine 1-phosphate receptor 3

1

9

High-throughput

0.445

High

1349316

PLIN2
Perilipin-2

1

1

High-throughput

0.445

High

1349349

FZD10
Frizzled-10

1

4

High-throughput

0.445

High

106326

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

246794

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.437

High

412296

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

589223

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

696006

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

731487

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.437

High

768705

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

845459

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

1

High-throughput

0.437

High

867287

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.437

High

948158

DJB13
DnaJ homolog subfamily B member 13

1

4

High-throughput

0.437

High

970815

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

1096760

RFA4
Replication protein A 30 kDa subunit

1

5

High-throughput

0.437

High

1128786

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.437

High

1149941

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.437

High

1164056

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

5

High-throughput

0.437

High

1249040

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1276517

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1349297

DCA11
DDB1- and CUL4-associated factor 11

1

2

High-throughput

0.437

High

1349301

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.437

High

1349308

PF21A
PHD finger protein 21A

1

2

High-throughput

0.437

High

1349347

RCOR1
REST corepressor 1

1

1

High-throughput

0.437

High

908037

VAMP7
Vesicle-associated membrane protein 7

1

0

High-throughput

0.426

High

1349348

PALD
Paladin

1

0

High-throughput

0.426

High

1349350

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.426

High

50634

HACL2
2-hydroxyacyl-CoA lyase 2

1

5

High-throughput

0.407

High

171523

S27A2
Long-chain fatty acid transport protein 2

1

5

High-throughput

0.407

High

321775

AGRL1
Adhesion G protein-coupled receptor L1

1

1

High-throughput

0.407

High

619864

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.407

High

648297

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

1

High-throughput

0.407

High

683291

TNR5
Tumor necrosis factor receptor superfamily member 5

1

1

High-throughput

0.407

High

732934

GASR
Gastrin/cholecystokinin type B receptor

1

2

High-throughput

0.407

High

1165223

F187B
Protein FAM187B

1

1

High-throughput

0.407

High

1175880

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

2

High-throughput

0.407

High

1219521

ANR22
Ankyrin repeat domain-containing protein 22

1

2

High-throughput

0.407

High

1227109

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.407

High

1240907

S27A4
Long-chain fatty acid transport protein 4

1

5

High-throughput

0.407

High

1279063

RIC3
Protein RIC-3

1

2

High-throughput

0.407

High

1323307

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

3

High-throughput

0.407

High

1335639

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

1349305

S35B4
Nucleotide sugar transporter SLC35B4

1

3

High-throughput

0.407

High

1349306

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

3

High-throughput

0.407

High

1349312

SMIM8
Small integral membrane protein 8

1

1

High-throughput

0.407

High

1349330

S35B3
Adenosine 3'-phospho 5'-phosphosulfate transporter 2

1

3

High-throughput

0.407

High

1349340

OCAD1
OCIA domain-containing protein 1

1

4

High-throughput

0.407

High

1349343

MTCH1
Mitochondrial carrier homolog 1

1

3

High-throughput

0.407

High

1155164

EREP1
Endosomal transmembrane epsin interactor 1

3

0

High-throughput

0.347

High

702814

5HT2C
5-hydroxytryptamine receptor 2C

3

0

High-throughput

0.345

High

1233839

GRAM4
GRAM domain-containing protein 4

3

0

High-throughput

0.345

High

1326195

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.318

High

1022430

IDD
Integral membrane protein DGCR2/IDD

2

0

High-throughput

0.313

High

335663

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.279

Low

1132563

FXYD3
FXYD domain-containing ion transport regulator 3

1

0

High-throughput

0.279

Low

1277742

TMC4
Voltage-gated chloride channel TMC4

1

0

High-throughput

0.279

Low

1349309

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.279

Low

1349317

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1349320

TMED9
Transmembrane emp24 domain-containing protein 9

1

0

High-throughput

0.279

Low

1349325

T126A
Transmembrane protein 126A

1

0

High-throughput

0.279

Low

1349339

PLS4
Phospholipid scramblase 4

1

0

High-throughput

0.279

Low

1178268

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1271747

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1349303

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

1349341

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1349338

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

1084

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

49459

TM223
Transmembrane protein 223

1

0

High-throughput

0.232

Low

184198

RER1
Protein RER1

1

0

High-throughput

0.232

Low

278910

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.232

Low

904027

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.232

Low

1212271

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.232

Low

1273776

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.232

Low

1289139

OSTA
Organic solute transporter subunit alpha

1

0

High-throughput

0.232

Low

1333865

MFSD9
Major facilitator superfamily domain-containing protein 9

1

0

High-throughput

0.232

Low

1340880

HUS1B
Checkpoint protein HUS1B

1

0

High-throughput

0.232

Low

1349311

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

0

High-throughput

0.232

Low

1349345

B4GT7
Beta-1,4-galactosyltransferase 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025