HitPredict

Interactor 1: CTNB1 (Q02248)
Catenin beta-1 (Beta-catenin)
Gene: Ctnnb1

Interactor 2: Q8BNP7 (Q8BNP7)
Adenomatous polyposis coli N-terminal dimerisation domain-containing protein
Gene: Apc

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	12874278, 20211142, 9554852, 15327768, 16611247
Identification Methods	two hybrid, affinity chromatography technology, pull down, x-ray crystallography
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	APC_15aa~Arm, APC_rep~Arm, Arm~Arm
Common GO terms	GO:0001708 - cell fate specification GO:0016342 - catenin complex GO:0030877 - beta-catenin destruction complex GO:0045595 - regulation of cell differentiation GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 781 Mm			1 1056
+	Rn
		936837 CTNB1_RAT (1-781): 0: 650: 99.87		APC_RAT (1-1056): 0: 1656: 96.21
+	Hs
		626060 CTNB1_HUMAN (1-781): 0: 650: 99.87		APC_HUMAN (1-1056): 0: 1621: 95.09
+	Hs
		542190 PLAK_HUMAN (7-755): 1.54e-159: 482: 66.89		APC_HUMAN (1-1056): 0: 1621: 95.09
+	Hs
		330154 CTNB1_HUMAN (1-781): 0: 650: 99.87		APCL_HUMAN (2-979): 0: 1242: 49.95
+	Dm
		578701 ARM_DROME (25-780): 2.58e-163: 495: 67.00		Q9VAS9_DROME (230-789): 0: 668: 47.73
+	Dm
		578806 ARM_DROME (25-780): 2.58e-163: 495: 67.00		Q9Y1T2_DROME (325-748): 1.66e-180: 556: 48.49
+	Dm
		578682 ARM_DROME (25-780): 2.58e-163: 495: 67.00		Q961B0_DROME (325-748): 4.75e-180: 555: 48.49
+	Ce
		218221 HMP2_CAEEL (89-662): 8.55e-125: 390: 34.16		APR1_CAEEL (272-766): 3.51e-157: 498: 27.78
+	Ce
		1090342 BAR1_CAEEL (129-705): 1.32e-96: 320: 25.52		APR1_CAEEL (272-766): 3.51e-157: 498: 27.78