HitPredict

Interactor 1: APBA1 (Q02410)
Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1)
Gene: APBA1

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26186194, 28514442, 14960569, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~PDZ, PDZ~PID
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 837 Hs			1 197
+	Hs
		970739 APBA1_HUMAN (1-837): 0: 635: 100.00		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Mm
		70738 APBA1_MOUSE (1-837): 0: 622: 92.76		LIN7C_MOUSE (1-197): 1.38e-57: 181: 100.00
+	Hs
		158274 APBA1_HUMAN (1-837): 0: 635: 100.00		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Hs
		159194 APBA1_HUMAN (1-837): 0: 635: 100.00		CSKP_HUMAN (13-194): 1.3e-30: 119: 20.53
+	Hs
		942327 APBA1_HUMAN (1-837): 0: 635: 100.00		DLG4_HUMAN (59-195): 2.19e-23: 98.7: 26.76
+	Hs
		970694 APBA1_HUMAN (1-837): 0: 635: 100.00		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Ce
		184638 LIN10_CAEEL (354-837): 1.55e-80: 281: 49.02		Q9U245_CAEEL (3-195): 2.33e-42: 142: 67.88
+	Dm
		677693 Q5BI79_DROME (453-837): 3.24e-78: 279: 61.92		DLG1_DROME (57-176): 1.06e-14: 73.6: 28.00
+	Mm
		1143366 LRRC7_MOUSE (12-742): 6.58e-62: 230: 12.99		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Hs
		942369 LRRC7_HUMAN (48-742): 1.27e-61: 229: 13.10		DLG4_HUMAN (59-195): 2.19e-23: 98.7: 26.76
+	Rn
		677773 LRRC7_RAT (12-742): 4.08e-61: 227: 12.99		DLG4_RAT (59-195): 2.17e-23: 98.7: 26.76
+	Mm
		1143467 DLG2_MOUSE (329-735): 1.13e-36: 150: 10.93		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Hs
		942349 DLG2_HUMAN (329-735): 7.38e-36: 148: 10.93		DLG4_HUMAN (59-195): 2.19e-23: 98.7: 26.76
+	Hs
		1021501 DLG2_HUMAN (329-735): 7.38e-36: 148: 10.93		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Rn
		1144014 DLG2_RAT (329-735): 6.55e-37: 151: 10.93		DLG1_RAT (94-178): 2.77e-21: 92.5: 37.78
+	Mm
		936188 DLG2_MOUSE (329-735): 1.13e-36: 150: 10.93		DLG3_MOUSE (60-164): 3.31e-21: 92.5: 32.73
+	Hs
		1077285 DLG2_HUMAN (329-735): 7.38e-36: 148: 10.93		DLG3_HUMAN (74-164): 2.8e-20: 89.8: 35.42
+	Mm
		1113136 Q3UP61_MOUSE (226-758): 1.1e-29: 128: 12.48		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Hs
		1232884 LNX2_HUMAN (387-824): 1.05e-33: 140: 14.99		LNX1_HUMAN (14-179): 1.21e-17: 82.1: 22.02
+	Mm
		250592 LNX1_MOUSE (310-820): 3.13e-29: 126: 13.54		LNX1_MOUSE (14-179): 4.23e-18: 83.3: 22.62