HitPredict

Interactor 1: DSG1 (Q02413)
Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)
Gene: DSG1

Interactor 2: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9443898
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cadherin~Cadherin
Common GO terms	GO:0001533 - cornified envelope GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules GO:0030057 - desmosome and 1 others more... GO:0098609 - cell-cell adhesion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1049 Hs			1 901
+	Hs
		971010 DSG2_HUMAN (2-1048): 0: 742: 32.40		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		521924 DSG2_HUMAN (2-1048): 0: 742: 32.40		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		970760 DSG1_HUMAN (1-1049): 0: 1147: 100.00		DSC1_HUMAN (4-464): 2.89e-45: 178: 14.46
+	Gg
		702742 CAD13_CHICK (43-590): 5.64e-156: 481: 26.80		CAD13_CHICK (14-678): 0: 626: 32.31
+	Hs
		521832 CADH8_HUMAN (19-483): 7.57e-84: 290: 18.98		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		877554 CAD12_HUMAN (4-483): 8.79e-89: 304: 20.83		CAD24_HUMAN (122-896): 0: 618: 24.55
+	Hs
		995966 DSG2_HUMAN (2-1048): 0: 742: 32.40		DSC1_HUMAN (4-464): 2.89e-45: 178: 14.46
+	Mm
		1108675 Q3KNZ1_MOUSE (19-483): 8.2e-83: 287: 19.47		Q3KNZ1_MOUSE (4-345): 5.12e-52: 197: 17.39
+	Hs
		877538 CAD12_HUMAN (4-483): 8.79e-89: 304: 20.83		CADH8_HUMAN (4-345): 1.52e-44: 175: 20.66
+	Hs
		580215 CAD11_HUMAN (19-487): 6.77e-79: 276: 18.00		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		1377989 PCDBD_HUMAN (58-721): 5.62e-106: 351: 18.62		PCDBB_HUMAN (477-856): 3.81e-26: 117: 11.69
+	Mm
		956163 CADH8_MOUSE (19-483): 4.32e-83: 288: 18.57		CADH8_MOUSE (4-345): 1.1e-44: 175: 20.94
+	Hs
		1377975 PCDBD_HUMAN (58-721): 5.62e-106: 351: 18.62		PCDB3_HUMAN (517-878): 1.66e-23: 108: 9.66
+	Dr
		1265005 CADH2_DANRE (19-483): 5.53e-69: 250: 20.65		CADH2_DANRE (4-462): 4.34e-52: 199: 15.74
+	Hs
		580214 CADH2_HUMAN (19-489): 1.77e-64: 237: 18.71		CADH4_HUMAN (4-462): 1.17e-56: 212: 14.32
+	Mm
		544690 CADH2_MOUSE (19-489): 2.43e-66: 243: 18.91		CADH2_MOUSE (4-385): 7.27e-53: 201: 15.35
+	Mm
		877549 CAD11_MOUSE (19-487): 2.17e-78: 275: 17.20		CAD11_MOUSE (4-349): 4.31e-40: 161: 20.27